Results 61 to 70 of about 37,295 (243)
Thalidomide alleviated IgA nephropathy through “gut-kidney axis”
Linchuang shenzangbing zazhiObjective Thalidomide has anti-inflammatory, immunomodulatory and renoprotective effects. However, its study in IgA nephropathy has remained scarce. The aim was to explore the role and possible mechanism of thalidomide in IgA nephropathy.
Rui-hua Wang +3 more
doaj +1 more source
Reversible Pulmonary Hypertension Related to Thalidomide Treatment for Multiple Myeloma
Case Reports in Oncology, 2011 Multiple myeloma (MM) is thrombogenic as a consequence of multiple hemostatic effects. Thalidomide is an effective treatment; however, it has been associated with an increased risk of thromboembolic events including pulmonary hypertension (PH). PH in the
Antonio Villa +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker +4 more
wiley +1 more source
, 2022 Yumeng Kang,1 Chuanxi Zhang,1 Yang He,1 Ziyan Zhang,1 Heliang Liu,2 Zhongqiu Wei,3 Jie Yang1 1Department of Dermatology, Affiliated Hospital of North China University of Science and Technology, Tangshan, People’s Republic of China; 2Hebei Key Laboratory ...
Liu H +6 more
core
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
Haematologica, 2012 Background Thalidomide has potent antimyeloma activity, but no prospective, randomized controlled trial has evaluated thalidomide monotherapy in patients with relapsed/refractory multiple myeloma.Design and Methods We conducted an international ...
Martin Kropff +17 more
doaj +1 more source
Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart +6 more
wiley +1 more source
Canadian Journal of Gastroenterology and Hepatology, 2020 Objective. To observe the effects of thalidomide on 2,4,6-trinitrobenzenesulfonic acid- (TNBS-) induced experimental colitis in rats and to explore the possible mechanism of thalidomide in the treatment of CD. Methods.
Ying Xie +5 more
doaj +1 more source
The effect of thalidomide on visceral fat pad mass and triglyceride concentration of the skeletal muscles in rats [PDF]
Yeungnam University Journal of Medicine, 2018 Background Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the ...
Ki-Hoon Kim +2 more
doaj +1 more source
Thalidomide in Cancer Treatment
, 2002 There is increased interest in the treatment of cancer with thalidomide because of its antiangiogenic, immunomodulating and sedative effects. In animal models, the antitumour activity of thalidomide is dependent on the species, route of administration ...
Kestell, Philip +7 more
core +1 more source