Results 81 to 90 of about 54,104 (311)
Blood, 2019 Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic agents, active in a number of hematologic malignancies. However, we currently have a limited understanding of the determinants
A. Sperling +21 more
semanticscholar +1 more source
Structural dynamics of the cereblon ligand binding domain.
PLoS ONE, 2015 Cereblon, a primary target of thalidomide and its derivatives, has been characterized structurally from both bacteria and animals. Especially well studied is the thalidomide binding domain, CULT, which shows an invariable structure across different ...
Marcus D Hartmann +4 more
doaj +1 more source
Structural basis of thalidomide enantiomer binding to cereblon
Scientific Reports, 2018 Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here,
Tomoyuki Mori +9 more
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan +4 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019 BACKGROUND Rosacea is a chronic inflammatory skin disorder of uncertain etiology. Evidence suggests the underlying pathogenesis is modulated by abnormal inflammatory and vascular responses.
Mengting Chen +11 more
semanticscholar +1 more source
Actions of thalidomide in producing vascular relaxations
, 2010 We have investigated the cardiovascular actions of thalidomide in vivo and in vitro. Blood pressure was recorded in pentobarbitone anaesthetized rats. Isometric contractions were examined in rings of rat tail artery and aorta. Radioligand binding studies
James R. Docherty +7 more
core +1 more source
ELECTROPHORESIS, EarlyView.Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Gerhard K. E. Scriba
wiley +1 more source
Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.
Blood, 2018 Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q).
E. Fink +31 more
semanticscholar +1 more source