Results 101 to 110 of about 37,295 (243)
Thalidomide Increases Human Keratinocyte Migration and Proliferation [PDF]
, 1999 Thalidomide is reported to have therapeutic utility in the treatment of pyoderma gangrenosum, Behçet’s disease, aphthous ulcers, and skin wounds. We investigated the effect of thalidomide on human keratinocyte proliferation and migration, two early and ...
Nasca, Maria R. +4 more
core +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
Actions of thalidomide in producing vascular relaxations
, 2010 We have investigated the cardiovascular actions of thalidomide in vivo and in vitro. Blood pressure was recorded in pentobarbitone anaesthetized rats. Isometric contractions were examined in rings of rat tail artery and aorta. Radioligand binding studies
James R. Docherty +7 more
core +1 more source
Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis
International Journal of Dermatology, EarlyView.Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller +11 more
wiley +1 more source
Journal of Anatomy, EarlyView.The chicken embryo is an accessible, low‐cost and genetically tractable model for studying limb development and congenital limb differences. We directly compared chicken and human limb musculature using published evidence alongside our own data and observations.
Julia Dong Hwa Oh +4 more
wiley +1 more source
Data in Brief, 2015 Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic ...
Xiugong Gao +2 more
doaj +1 more source
Facile Synthesis of Thalidomide
, 2019 We report a simple and facile procedure for the preparation of thalidomide in two steps with a high overall yield (56%). The preparation was composed of a reaction between anhydride phthalic and l-glutamic acid to form N-phthaloyl-dl-glutamic acid (IV ...
Dinh Chau Phan (6899015) +5 more
core +1 more source
Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil—A Literature Review
Oral Diseases, EarlyView.ABSTRACT Background Recurrent aphthous stomatitis (RAS) is a common yet therapeutically challenging chronic inflammatory disease of the oral mucosa, characterized by recurrent, painful ulcerations that substantially affect patients' quality of life. Objective This review summarizes current evidence on phytotherapy in RAS, with particular focus on the ...
Ruzica Ivkovic +4 more
wiley +1 more source
Atrophic Papulosis: A Systematic Review of Pediatric Cases
Pediatric Dermatology, EarlyView.ABSTRACT Background Atrophic papulosis is a rare occlusive vasculopathy that can present with isolated cutaneous disease or with systemic involvement. Pediatric cases are uncommon, and existing reports are heterogeneous, limiting understanding of disease patterns, timing of organ involvement, and outcomes.
Ou Jia Emilie Wang +4 more
wiley +1 more source