Results 111 to 120 of about 37,295 (243)

Thalidomide for managing cancer cachexia.

, 2012
Cancer cachexia is a multidimensional syndrome characterised by wasting, loss of weight, loss of appetite, metabolic alterations, fatigue and reduced performance status. A significant number of patients with advanced cancer develop cachexia before death.
Donnelly, Michael; id_orcid, Cardwell, Christopher; id_orcid, Cantwell, Marie, Reid, Joanne; id_orcid, Mills, Moyra, Murray, Liam   +5 more
core   +1 more source

Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma

Saudi Journal of Kidney Diseases and Transplantation, 2019
Thalidomide, which is an angiogenesis inhibitor and immunomodulator that reduces tumor necrosis factor-alpha, has regained value in the treatment of multiple myeloma. Serious pulmonary complications due to thalidomide use remain relatively uncommon.
Zohra El Ati, Rais Lamia, Jouda Cherif, Hela Jbali, Lilia Ben Fatma, Ikram Mami, Rania Khedher, Wided Smaoui, Madiha Krid, Fethi Ben Hamida, Soumaya Beji, Mohamed Karim Zouaghi   +11 more
doaj   +1 more source

Challenges of Dengue in Hematological Disease Patients: Descriptive Analysis From the DANGO Registry During the 2023–2024 Outbreak in Argentina

Transplant Infectious Disease, EarlyView.
During the 2023–2024 Argentine dengue outbreak, 33 patients with hematological disease showed high complication rates, frequent hospitalization (64%), severe thrombocytopenia (90%), and 6% dengue‐attributable mortality. Transfusion‐associated cases were documented.
Gustavo Adolfo Méndez, Carla Niveyro, Pedro Andrés Villalba Apestegui, Victoria Isabel Martin, Lucila María Compañy Kec, María Cynthia Tomasino, Mariana del Carmen del Marull, Haydee Ingrid Bernard, Claudia Patricia Lorena Fernández, Flavia Marcela Pelech, Maria Fernanda Tosin, María Fernanda González‐Hobecker, Karen Beatrice Duranona, Angela Daiana Jara, Justus Cornely, Oliver A. Cornely, Jon Salmanton‐García   +16 more
wiley   +1 more source

Thalidomide in cancer medicine

, 2004
Thalidomide, an oral agent with antiangiogenic and immunomodulatory properties, is being investigated extensively in the management of advanced cancer. Multiple studies with large numbers of patients have confirmed that this drug has significant activity
Eleutherakis-Papaiakovou, V, Bamias, A, Dimopoulos, MA   +2 more
core   +1 more source

Renal and Functional Vulnerability in Hansen Disease: A Framework for Chronic Infectious Disability in Endemic Settings

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives Hansen disease is a neglected infectious disease associated with reactional inflammation, neuropathy and long‐term disability. Renal involvement and sarcopenia have been described separately, but their clinical coexistence has received limited attention. This review examines evidence for a hypothesised renal–functional vulnerability
Kleberson de Oliveira, Lucas Maciel de Almeida Corrêa, Isabela Malerba Pinheiro, Alexandre de Assis Barbosa, Maria Eduarda Castro Gonçalves, Lara Lucena Fernandes Filgueiras, Lara Reis Gomes de Mello Queiroz   +6 more
wiley   +1 more source

Thalidomide does not interact with P-glycoprotein.

, 2006
BACKGROUND There is growing clinical interest in thalidomide for the treatment of various disorders due to its anti-inflammatory, immunomodulatory, and anti-angiogenic properties.
Zimmermann C, Gutmann H, Drewe J
core   +1 more source

Real‐world outcomes of daratumumab, bortezomib, thalidomide and dexamethasone (Dara‐VTd) induction and lenalidomide maintenance in transplant‐eligible multiple myeloma

British Journal of Haematology, EarlyView.
Edvan Q. Crusoé, Glaciano Ribeiro, João Tadeu D. Souto Filho, Jayr Schmidt Filho, Natalia Schutz, Milton A. F. Aranha, Abel Costa, Abrahao Hallack, Fernando V. Pericole, Juliana S. Lima, Breno Gusmão, Eduardo Flávio O. Ribeiro, Jorge P. Vaz, Rosane Bittencourt, Rafael Cunha, Danielle Ovigli, Luiza Berg, Ederson R. Mattos, Angelo Maiolino, Vania Hungria, on behalf of GBRAM   +20 more
wiley   +1 more source

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcoma.
Csilla Fejös, Felicitas Czichon, Maureen Griffin, Natalie Grillo, Quentin Fournier, Michelle L. Oblak, Mikaela Eng‐Toogood, Michael Kent, Isabelle Desmas‐Bazelle, Miriam Kleiter, Laura Marconato, Katie McNaught, Simona Vincenti, Carmit Chalfon, Petros Odatzoglou, Carla Rohrer Bley   +15 more
wiley   +1 more source

Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects [PDF]

, 2002
Stirling, D, H-W Man, J B Marriott, Dredge, K, Chen, R, Muller, GW, R Chen, A G Dalgleish, Dalgleish, AG, Man, HW, G W Muller, D Stirling, Marriott, JB, C D Macdonald, Macdonald, CD, K Dredge   +15 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source