Results 131 to 140 of about 37,295 (243)
MedComm, Volume 7, Issue 10, October 2026.The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley +1 more source
Khyber Medical University JournalOBJECTIVE: To identify the effectiveness and safety of thalidomide in transfusion-dependent beta Thalassemia Major (TDBTM) patients. METHODS: A comprehensive search of PubMed, Cochrane Library, and Embase was conducted between January 01, 2014, and ...
Tahira Atta +4 more
doaj +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
MedComm, Volume 7, Issue 10, October 2026.Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
Beyond Thalidomide: Birth defects explained [PDF]
, 2007 How do birth defects happen? What goes wrong in the embryo? These perennial questions were brought into sharp focus in the wake of the thalidomide catastrophe (1958–1962). How did thalidomide mutilate the embryo? Despite research efforts, these questions
McCredie, Janet
core
Stability Study of a Thalidomide Suspension
, 2012 Thalidomide is being used increasingly for its immunomodulatory, anti-inflammatory and anti-angiogenic properties. Data on the stability of an oral liquid thalidomide formulation for use in patients with swallowing difficulties and enteral feeding tubes ...
Cuong D Tang +5 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.From symptom relief to multimodal care: duloxetine and amitriptyline may reduce established CIPN‐related pain and provide a therapeutic foundation for future combination strategies. ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by neuropathic pain, sensory ...
Rosamaria Caminiti +13 more
wiley +1 more source
Extramedullary multiple myeloma escapes the effect of thalidomide
Haematologica, 2004 BACKGROUND AND OBJECTIVES: Thalidomide is an antiangiogenic drug that produces a response rate ranging from 32 to 64% in patients with refractory/relapsed multiple myeloma (MM).
L Rosinol +9 more
doaj
, 2019 Thalidomide\u27s mechanism of action as an infamous teratogen remains an unsolved mystery. The literature contains more than 30 theories explaining the human “thalidomide tragedy”.
Keller, Samuel
core
Corneal endothelial abnormalities associated with thalidomide toxicity
, 2005 Purpose: To describe bilateral corneal endothelial abnormalities associated with thalidomide toxicity. Methods: Observational case report. Results: A 30-year-old man, born with bilateral hypoplastic upper limb defects (phocomelia) caused by thalidomide ...
Batterbury, Mark +3 more
core +1 more source
‘From the Fields Into the Bars’: The Story of Israel's First Transgender Novel, The Cut (1977)
Gender &History, Volume 38, Issue 3, Page 958-969, October 2026.ABSTRACT In 1977, an Israeli transgender woman, Judy Spotheim, published an autobiographical novel entitled The Cut. It describes the emergence of a trans community in the commercial‐sex areas of Tel Aviv‐Jaffa, hoping to humanise trans women (coccinelles). This article is the first to study the novel and present a biography of Spotheim.
Gil Engelstein, Iris Rachamimov
wiley +1 more source