Results 121 to 130 of about 37,295 (243)

Thalidomide and a Thalidomide Analogue Drug Costimulate Virus-Specific CD8+ T Cells In Vitro

, 2003
CD8+ T cell immunity is critical for protection from viral disease, such as that caused by the human immunodeficiency virus (HIV) or cytomegalovirus (CMV). It is therefore important to identify therapies that can boost antiviral immunity.
Kaplan, Gilla, Muller, George, Haslett, Patrick A. J, Hanekom, Willem A   +3 more
core   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Systemic Bevacizumab for Severe Bleeding From Acquired Gastrointestinal Vascular Malformations

American Journal of Hematology, Volume 101, Issue 10, Page 2605-2615, October 2026.
Targeted antiangiogenic therapy with systemic bevacizumab for bleeding from acquired GI VMs was found to be safe and effective for chronic and severe bleeding from acquired vascular malformations due to idiopathic angiodysplasia, chronic liver disease, and deficiencies of von Willebrand factor, in a patient population comprised mostly of heavily ...
Nardeen E. Ayad, Jacob R. Anderson, Bimalangshu Dey, Rebecca Karp Leaf, Andrew B. Song, Hanny Al‐Samkari   +5 more
wiley   +1 more source

Thalidomide Metabolism and Metabolites

, 2004
Thalidomide, renowned for causing birth defects in the late 1950s when used for the relief of morning sickness, has attracted new interest for the treatment of inflammatory conditions such as erythema nodosum leprosum and human malignancies such as ...
Lu, Jun
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Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3365-3374, October 2026.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources

Thalidomide as Treatment of Lip’s Pyogenic Granuloma

Liyan Lai,1,* Jiayao Nie,2,* Dejian Duan,3 Dan Huang2 1The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, People’s Republic of China; 2Department of Dermatology, Shenzhen Traditional Chinese Medicine ...
Huang D, Nie J, Duan D, Lai L
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Inhibition of IL-12 production by thalidomide.

, 1997
The immunomodulatory properties of thalidomide are currently being exploited therapeutically in conditions as diverse as erythema nodosum leprosum, chronic graft-vs-host disease, rheumatoid arthritis, and sarcoidosis.
Wahl, Larry, Trinchieri, Giorgio, Ma, Xiaojing, Karp, Christopher L., Flockhart, David A., Moller, David R., Wysocka, Maria, Greenlee, Brian M.   +7 more
core   +1 more source

Treatment Patterns and Clinical Outcomes Among Chinese Patients With Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Study (CHAMP‐MM)

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT The therapeutic landscape for newly diagnosed multiple myeloma (NDMM) in China has evolved significantly with wider access to novel agents, including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and CD38 monoclonal antibodies.
Jian Cui, Xiaoyan Qu, Chunrui Li, Fei Li, Liye Zhong, Xiaohong Fu, Gang Liu, Lugui Qiu, Gang An   +8 more
wiley   +1 more source

Thalidomide does not interact with P-glycoprotein [PDF]

, 2018
Background: There is growing clinical interest in thalidomide for the treatment of various disorders due to its anti-inflammatory, immunomodulatory, and anti-angiogenic properties. In numerous clinical trials thalidomide is used as an adjunct to standard
Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen   +2 more
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