Results 111 to 120 of about 28,628 (268)

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ_1–40Peptides [PDF]

, 2009
Huaqi Xiong, Debbie Callaghan, Aimee Jones, Jianying Bai, Ingrid Rasquinha, Catherine Delano Smith, Ke Pei, Douglas G. Walker, Lih‐Fen Lue, Danica Stanimirovic, Wandong Zhang   +10 more
openalex   +1 more source

Sporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policy

Неврология, нейропсихиатрия, психосоматика, 2018
The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders.
A. A. Kulesh, V. E. Drobakha, V. V. Shestakov   +2 more
doaj   +1 more source

Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension—A Mendelian Randomization Study Combining CHARLS

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study shows alcohol increases intracerebral hemorrhage risk (OR = 1.21), while red wine reduces it (two‐sample MR OR = 0.61; multivariable MR OR = 0.55), partly via lowering hypertension (mediation = 13.45%). CHARLS data find wine drinkers (especially elderly males) have lower hypertension (OR = 0.54), and this holds after multivariable logistic ...
Fuan Zhang, Ning Ding, Lanying Zhang, Ping Zhang, Rui Liu, Ziqiang Chen, Jiao Chen, Huanhuan Li, Shengtao Yao   +8 more
wiley   +1 more source

Relationship between cerebral amyloid angiopathy and plasma homocysteine levels in Alzheimer’s disease [PDF]

, 2020
Kazutomi Kanemaru, Akiko Kanemaru, Shigeo Murayama   +2 more
openalex   +1 more source

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

Inflammatory cerebral amyloid angiopathy with poor outcome – case report

, 2023
Dariusz Dziubek, Karolina Dziubek
openalex   +2 more sources

Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy

MedComm, Volume 6, Issue 12, December 2025.
This graphical abstract summarizes the major components of this review on Parkinson's disease, including epidemiological trends, risk factor classification, peripheral and molecular pathogenesis, and both preventive and therapeutic strategies. The framework reflects the multidimensional organization of the text, covering disease burden, mechanistic ...
Xue‐Yao Guo, Dong‐Yan Song, Ming‐Yang Wu, Jing‐Qi Zhang, Jia‐Yi Li, Lin Yuan   +5 more
wiley   +1 more source

Advances in cerebral amyloid angiopathy imaging

Therapeutic Advances in Neurological Disorders, 2019
Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease ...
Szu-Ju Chen, Hsin-Hsi Tsai, Li-Kai Tsai, Sung-Chun Tang, Bo-Chin Lee, Hon-Man Liu, Ruoh-Fang Yen, Jiann-Shing Jeng   +7 more
doaj   +1 more source

Monoclonal Antibody Therapies in Alzheimer's Disease: A Guide for Emergency Physicians

Emergency Medicine Australasia, Volume 37, Issue 6, December 2025.
ABSTRACT Whilst the advent of novel disease‐modifying medications for Alzheimer's disease represents potential benefit for patients and caregivers, they may be associated with adverse events that present important considerations for emergency and primary care. This article seeks to highlight some of the challenges Emergency Departments may encounter in
Scott Wrigley, Andrew L. H. Huynh, Sanka Amadoru, Henry Zeimer, Irene Tan, Michael Woodward, George Braitberg, Paul Andrew Yates   +7 more
wiley   +1 more source