Results 111 to 120 of about 32,043 (291)

Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease [PDF]

, 2017
Amyloid beta peptides (A\b{eta}), implicated in Alzheimers disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes changes in aging and AD. We designed multi component lipid models to mimic healthy and diseased states of the neuronal membrane. Using atomic force microscopy (AFM), Kelvin probe
arxiv   +1 more source

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Stroke, 2019
Background and Purpose— Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study,
W. Freeze, B. Bacskai, M. Frosch, H. Jacobs, W. Backes, S. Greenberg, Susanne J. van Veluw   +6 more
semanticscholar   +1 more source

An autopsy case of amyloid β-related angiitis with cognitive impairment, multiple infarcts and subcortical hemorrhage

Human Pathology: Case Reports, 2018
A 76-year-old female presented with cognitive impairment and multiple brain infarcts and died of massive subcortical cerebral hemorrhage. A premortem clinical diagnosis was not possible.
Takahiro Watanabe, MD, PhD, Shinichiro Ukon, MD, Takako Kihara, MD, Yoshi-Hiro Ide, MD, PhD, Shohei Matsuo, MD, Yuka Hayashi, MD, Shuhei Kasama, MD, PhD, Hiroo Yoshikawa, MD, PhD, Yuki Okano, Chiaki Uchida, Masahiro Yamamoto, Hiroyuki Hao, MD, PhD, Akio Kimura, MD, PhD, Seiichi Hirota, MD, PhD, Yoshitane Tsukamoto, MD, PhD   +14 more
doaj  

Atomic-resolution structures of prion AGAAAAGA amyloid fibrils [PDF]

Published in [Amyloids: Composition, Functions and Pathology, Editors Irene P. Halcheck and Nancy R. Vernon, NOVA Science Publishers, Hauppauge, N.Y., March 1st 2012, ISBN 978-1-62100-538-4, hardcover], Chapter 10, pp.177-186, 2011
To the best of the author's knowledge, there is little structural data available on the AGAAAAGA palindrome in the hydrophobic region (113-120) of prion proteins due to the unstable, noncrystalline and insoluble nature of the amyloid fibril, although many experimental studies have shown that this region has amyloid fibril forming properties and plays ...
arxiv  

Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals

Psychiatry and Clinical Neurosciences, Volume 79, Issue 6, Page 344-355, June 2025.
Aim The pathological criteria from the fourth Consortium on Dementia With Lewy bodies (DLB) in psychiatric cohorts has not been validated. Also, the pathological differences in prodromal DLB subtypes remain unclear. This study aimed to elucidate the clinicopathological features of patients with DLB in psychiatric hospitals.
Kazuhiro Takeda, Hiroshige Fujishiro, Youta Torii, Hirotaka Sekiguchi, Shusei Arafuka, Chikako Habuchi, Ayako Miwa, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda   +11 more
wiley   +1 more source

Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries

Nature Aging, 2022
Xinan Chen, Xiaodan Liu, S. Koundal, Rena Elkin, Xiaoyue Zhu, Brittany Monte, Feng Xu, Feng Dai, M. Pedram, Hedok Lee, J. Kipnis, A. Tannenbaum, W. V. Van Nostrand, H. Benveniste   +13 more
semanticscholar   +1 more source

Sporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policy

Неврология, нейропсихиатрия, психосоматика, 2018
The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders.
A. A. Kulesh, V. E. Drobakha, V. V. Shestakov   +2 more
doaj   +1 more source

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cerebrovascular amyloid-β deposition is highly implicated in the pathogenesis of cerebral amyloid angiopathy (CAA), one of the major causes of dementia.
Takayuki Inoue, S. Saito, Masashi Tanaka, H. Yamakage, T. Kusakabe, A. Shimatsu, M. Ihara, N. Satoh‐Asahara   +7 more
semanticscholar   +1 more source

Superficial siderosis in cerebral amyloid angiopathy

Annals of Indian Academy of Neurology, 2011
Wani Nisar, Kosar Tasleem, Rawa Aijaz, Qayum Abdul   +3 more
doaj   +4 more sources

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery

Acta Neuropathologica, 2018
Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA).
Z. Jaunmuktane, A. Quaegebeur, R. Taipa, M. Viana-Baptista, Raquel Barbosa, C. Koriath, R. Sciot, S. Mead, S. Brandner   +8 more
semanticscholar   +1 more source