Results 111 to 120 of about 42,785 (261)

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

Advances of cerebral amyloid angiopathy and related cognitive impairment

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease(cSVD) in clinic. It is characterized by the deposition of amyloid β-protein (Aβ) in the cerebral vascular wall, including small and medium arteries of pia mater and cortex and ...
Zhen ZHEN, Yan⁃jun GUO
doaj   +1 more source

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]

, 2005
In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc, Dermaut, Bart, Kumar-Singh, Samir, Rademakers, Rosa, Theuns, Jessie, Van Broeckhoven, Christine   +5 more
core   +1 more source

Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy

Neurology, 2019
Objective To assess the association of cortical superficial siderosis (cSS) presence and extent with future bleeding risk in cerebral amyloid angiopathy (CAA).
A. Charidimou, G. Boulouis, S. Greenberg, A. Viswanathan   +3 more
semanticscholar   +1 more source

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, Volume 36, Issue 2, March 2026.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy [PDF]

, 2017
The risk of future symptomatic intracerebral haemorrhage (sICH) remains uncertain in patients with acute convexity subarachnoid haemorrhage (cSAH) associated with suspected cerebral amyloid angiopathy (CAA).
Ambler, G, Banerjee, G, Hostettler, IC, Jäger, HR, Werring, DJ, Wilson, D   +5 more
core   +1 more source

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

Annals of Neurology, 2019
Amyloid‐β transmission has been described in patients both with and without iatrogenic Creutzfeldt–Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid‐β pathology during life.
G. Banerjee, M. Adams, Z. Jaunmuktane, G. Alistair Lammie, B. Turner, M. Wani, I. Sawhney, H. Houlden, S. Mead, S. Brandner, D. Werring   +10 more
semanticscholar   +1 more source

Cerebral amyloid angiopathy-linked β-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance We found an increased interaction between CAA-linked mutant Aβ and fibrin(ogen) that may not only result in severely altered fibrin structure and function but may also lead to vast amounts of fibrin(ogen)/Aβ codeposition, as well as fibrin ...
Steven A. Cajamarca, E. Norris, L. van der Weerd, S. Strickland, H. J. Ahn   +4 more
semanticscholar   +1 more source

Research progress of cerebral amyloid angiopathy associated with inflammation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Cerebral amyloid angiopathy associated with inflammation (CAA⁃I) is a rare subtype of cerebral amyloid angiopathy (CAA), and is increasingly recognized by neurologists. CAA⁃Iischaracterized by the pathological hallmarks of both CAA and vasculitis.
Wen⁃hao ZHANG, Ran LIU, Yi⁃ning HUANG   +2 more
doaj  

APOE genotype differentially modulates effects of anti-Aβ, passive immunization in APP transgenic mice [PDF]

, 2017
BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy.
Baquero-Buitrago, Jairo, Holtman, David M, Kim, Jungsu, Lopez-Contreras, Jennifer, Pankiewicz, Joanna E, Sadowski, Martin J, Sanchez, Sandrine, Sullivan, Patrick M   +7 more
core   +2 more sources