Results 121 to 130 of about 42,785 (261)

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, Volume 36, Issue 2, March 2026.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

An unexpected discovery of a novel potentially pathogenic APP gene variant: a case report of slowly progressive Alzheimer’s disease with prominent cerebral amyloid angiopathy

Frontiers in Neuroscience
Amyloid precursor protein (APP) plays an essential role in brain function and development. Variants in the APP gene are associated with both familial Alzheimer’s disease and cerebral amyloid angiopathy. We report a case of early onset, slowly progressive
Matyas Sykora, Matyas Sykora, Matyas Sykora, Marie Harmackova, Eva Parobkova, Eva Parobkova, Robert Rusina, Robert Rusina, Radoslav Matěj, Radoslav Matěj, Radoslav Matěj   +10 more
doaj   +1 more source

Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease [PDF]

, 2008
BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord.
Feldman, H., Forster, B., Mackenzie, I., Maia, L., Martzke, J., Woolfenden, A.   +5 more
core  

Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. [PDF]

, 2018
BACKGROUND AND PURPOSE:Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not typically observed near microbleeds, suggesting more subtle mechanisms, such as inflammation, may ...
Ahn, Sung Ji, Anrather, Josef, Nishimura, Nozomi, Schaffer, Chris B   +3 more
core   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers. METHODS The study involved 251 Wake Forest Multi‐Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, magnetic resonance imaging, amyloid positron emission ...
Samuel N. Lockhart, Courtney L. Sutphen, Jordan Tanley, Fernando Gonzalez‐Ortiz, Przemysław R. Kac, Mohamad Habes, Susan R. Heckbert, Nicholas J. Ashton, Michelle M. Mielke, Robert Koeppe, Marc D. Rudolph, Kiran K. Solingapuram Sai, Christopher T. Whitlow, Kevin D. Hiatt, Suzanne Craft, Thomas C. Register, Kathleen M. Hayden, Stephen R. Rapp, Bonnie C. Sachs, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Timothy M. Hughes   +22 more
wiley   +1 more source

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: Report of an autopsy case [PDF]

, 2008
The association of angiitis of central nervous system (ACNS) with cerebral amyloid angiopathy (CAA) suggests a physiopathological relationship between these two affections. Few cases are reported in patients with Alzheimer’s disease (AD).
C. Annweiler, C. Hommet, C. Lavigne, G. Berrut, J.P. Saint-André, M. Paccalin, O. Beauchet   +6 more
core   +1 more source

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases [PDF]

, 2015
Aim: Brain clusterin is known to be associated with the amyloid‐β deposits in Alzheimer's disease (AD). We assessed the distribution of clusterin immunoreactivity in cerebrovascular disorders, particularly focusing on white matter changes in small vessel
Borjesson-Hanson, A, Chen, A, Craggs, L, Deramecourt, V, Hagel, C, Kalaria, RN, Kalimo, H, Kuhlenbaeumer, G, Oakley, AE, Slade, JY, Taylor, J, Viitanen, M   +11 more
core   +1 more source

Progression of cerebral amyloid angiopathy: a pathophysiological framework

Lancet Neurology, 2023
E. Koemans, J. Chhatwal, S. J. Veluw, E. Etten, M. Osch, M. V. Walderveen, H. Sohrabi, M. Kozberg, Z. Shirzadi, G. Terwindt, M. Buchem, E. Smith, D. Werring, R. Martins, M. Wermer, S. Greenberg   +15 more
semanticscholar   +1 more source

High vulnerability of medial prefrontal pyramidal neurons in post‐stroke, vascular, Alzheimer's disease, and aging‐related dementias

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The medial prefrontal cortex (mPFC) is critical for executive function, behavioral inhibition, and memory. Its high vulnerability to dementia, compared to other prefrontal regions, remains unclear. METHODS We analyzed post mortem brain tissue from 118 older subjects, including post‐stroke survivors, Alzheimer's disease; vascular ...
Dan D. Jobson, Yoshiki Hase, Lauren Walker, Tuomo Polvikoski, Ahmad A. Khundakar, Louise Allan, Raj N. Kalaria   +6 more
wiley   +1 more source