Results 131 to 140 of about 43,093 (347)

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

Lancet Neurology, 2022
A. Charidimou, G. Boulouis, M. Frosch, J. Baron, M. Pasi, J. Albucher, G. Banerjee, Carmen Barbato, F. Bonneville, S. Brandner, L. Calvière, F. Caparros, B. Casolla, C. Cordonnier, M. Delisle, V. Deramecourt, M. Dichgans, Elif Gokcal, J. Herms, M. Hernández-Guillamon, H. Jäger, Z. Jaunmuktane, J. Linn, S. Martinez-Ramirez, E. Martínez-Sáez, C. Mawrin, J. Montaner, S. Moulin, J. Olivot, F. Piazza, L. Puy, N. Raposo, M. Rodrigues, S. Roeber, J. R. Romero, N. Samarasekera, J. Schneider, S. Schreiber, F. Schreiber, Corentin Schwall, Colin Smith, L. Szalardy, P. Varlet, A. Viguier, J. Wardlaw, Andrew D. Warren, F. Wollenweber, M. Zedde, M. Buchem, M. Gurol, A. Viswanathan, R. Salman, E. Smith, D. Werring, S. Greenberg   +54 more
semanticscholar   +1 more source

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

Annals of Clinical and Translational Neurology, 2019
Cerebral amyloid angiopathy (CAA) is caused by cerebrovascular deposition of β‐amyloid fragments leading to cerebrovascular dysfunction and other brain injuries.
C. Leurent, James A. Goodman, Yao Zhang, P. He, J. Polimeni, M. Gurol, Monica Lindsay, Linda Frattura, U. S. Sohur, A. Viswanathan, M. Bednar, Eric E. Smith, Charlotte David John Sandra Elizabeth Lawrence Sterling Cath Cordonnier Werring Black Honig Klijn Lee Restrepo, C. Cordonnier, D. Werring, S. Black, L. Honig, C. Klijn, Jin-moo Lee, L. Restrepo, C. Kase, S. Savitz, S. Greenberg   +22 more
semanticscholar   +1 more source

The history of Down syndrome–associated Alzheimer's disease; past, present, and future

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract The landscape of Down syndrome–associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations to the elucidation of complex genetic and molecular mechanisms.
Lucia Maure‐Blesa, María Carmona‐Iragui, Ira Lott, Elizabeth Head, Thomas Wisniewski, Michael S. Rafii, Joaquín Espinosa, Jesús Flórez, William C. Mobley, Anthony Holland, André Strydom, Shahid Zaman, Juan Fortea   +12 more
wiley   +1 more source

The Budapest Amyloid Predictor and its Applications [PDF]

arXiv, 2020
The amyloid state of proteins is widely studied with relevancy in neurology, biochemistry, and biotechnology. In contrast with amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and anti-parallel $\beta$-sheets in a periodically repeated formation.
arxiv  

Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease [PDF]

, 2017
Amyloid beta peptides (A\b{eta}), implicated in Alzheimers disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes changes in aging and AD. We designed multi component lipid models to mimic healthy and diseased states of the neuronal membrane. Using atomic force microscopy (AFM), Kelvin probe
arxiv   +1 more source

Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. [PDF]

, 2018
Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however, are coarse-grained and lack precise neuroanatomic localization.
Beckett, Laurel, Chuang, Kangway V, DeCarli, Charles, Dugger, Brittany N, Jin, Lee-Way, Keiser, Michael J, Tang, Ziqi   +6 more
core  

Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds [PDF]

, 2016
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI).
Choe, YS, Jung, N-Y, Kim, HJ, Kim, JS, Kim, S, Kim, YJ, Kim, YJ, Kwak, K-C, Lee, J-H, Lee, JM, Lee, K-H, Moon, SH, Na, DL, Park, J-H, Seo, SW, Werring, DJ, Woo, S-Y   +16 more
core   +1 more source

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Stroke, 2019
Background and Purpose— Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study,
W. Freeze, B. Bacskai, M. Frosch, H. Jacobs, W. Backes, S. Greenberg, Susanne J. van Veluw   +6 more
semanticscholar   +1 more source

An autopsy case of amyloid β-related angiitis with cognitive impairment, multiple infarcts and subcortical hemorrhage

Human Pathology: Case Reports, 2018
A 76-year-old female presented with cognitive impairment and multiple brain infarcts and died of massive subcortical cerebral hemorrhage. A premortem clinical diagnosis was not possible.
Takahiro Watanabe, MD, PhD, Shinichiro Ukon, MD, Takako Kihara, MD, Yoshi-Hiro Ide, MD, PhD, Shohei Matsuo, MD, Yuka Hayashi, MD, Shuhei Kasama, MD, PhD, Hiroo Yoshikawa, MD, PhD, Yuki Okano, Chiaki Uchida, Masahiro Yamamoto, Hiroyuki Hao, MD, PhD, Akio Kimura, MD, PhD, Seiichi Hirota, MD, PhD, Yoshitane Tsukamoto, MD, PhD   +14 more
doaj  

Atomic-resolution structures of prion AGAAAAGA amyloid fibrils [PDF]

Published in [Amyloids: Composition, Functions and Pathology, Editors Irene P. Halcheck and Nancy R. Vernon, NOVA Science Publishers, Hauppauge, N.Y., March 1st 2012, ISBN 978-1-62100-538-4, hardcover], Chapter 10, pp.177-186, 2011
To the best of the author's knowledge, there is little structural data available on the AGAAAAGA palindrome in the hydrophobic region (113-120) of prion proteins due to the unstable, noncrystalline and insoluble nature of the amyloid fibril, although many experimental studies have shown that this region has amyloid fibril forming properties and plays ...
arxiv