Results 131 to 140 of about 42,785 (261)

Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Recurrent hemorrhage represents a significant risk for patients with lobar hemorrhage and underlying cerebral amyloid angiopathy. However, it remains unknown, whether cerebrospinal fluid biomarkers of β‐amyloid (Aβ) retention, predict ...
Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber   +17 more
doaj   +1 more source

Familial multiple cavernous malformation syndrome : MR features in this uncommon but silent threat [PDF]

, 2016
Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon.
Lemmerling, Marc, Mespreuve, Marc, Vanhoenacker, Filip   +2 more
core   +3 more sources

Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline.
Alejandra O. Morcillo‐Nieto, Mateus Rozalem‐Aranha, Lucia Maure‐Blesa, Íñigo Rodríguez‐Baz, José Enrique Arriola‐Infante, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, Lídia Vaqué‐Alcázar, José Allende Parra, Zili Zhao, Javier Arranz, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +24 more
wiley   +1 more source

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

Annals of Clinical and Translational Neurology, 2019
Cerebral amyloid angiopathy (CAA) is caused by cerebrovascular deposition of β‐amyloid fragments leading to cerebrovascular dysfunction and other brain injuries.
C. Leurent, James A. Goodman, Yao Zhang, P. He, J. Polimeni, M. Gurol, Monica Lindsay, Linda Frattura, U. S. Sohur, A. Viswanathan, M. Bednar, Eric E. Smith, Charlotte David John Sandra Elizabeth Lawrence Sterling Cath Cordonnier Werring Black Honig Klijn Lee Restrepo, C. Cordonnier, D. Werring, S. Black, L. S. Honig, C. Klijn, Jin-moo Lee, L. Restrepo, C. Kase, S. Savitz, S. Greenberg   +22 more
semanticscholar   +1 more source

Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Neus Falgàs, Núria Tort‐Colet, Isabel Martín‐Sobrino, Gerard Mayà, Marta Peña‐González, Salvatore Rudilosso, Carles Gaig, Beatriz Bosch, Aurora Arqueros, Agnès Pérez‐Millan, Adrià Tort‐Merino, Guadalupe Fernández‐Villullas, Gerard Piñol‐Ripoll, Mircea Balasa, Albert Lladó, Manuel Morales Ruiz, Emma Muñoz‐Moreno, Oriol Grau‐Rivera, Alex Iranzo, Lea T. Grinberg, Raquel Sánchez‐Valle   +20 more
wiley   +1 more source

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Stroke, 2019
Background and Purpose— Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study,
W. Freeze, B. Bacskai, M. Frosch, H. Jacobs, W. Backes, S. Greenberg, Susanne J. van Veluw   +6 more
semanticscholar   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, Volume 99, Issue 2, Page 492-501, February 2026.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

Journal of Neurology Neurosurgery & Psychiatry, 2017
Cerebral amyloid angiopathy (CAA) has never been more relevant. The last 5 years have seen a rapid increase in publications and research in the field, with the development of new biomarkers for the disease, thanks to advances in MRI, amyloid positron ...
G. Banerjee, R. Carare, C. Cordonnier, S. Greenberg, J. Schneider, Eric E. Smith, M. van Buchem, J. van der Grond, M. Verbeek, D. Werring   +9 more
semanticscholar   +1 more source

Extensive Intracerebral Hemorrhage Involving Basal Ganglia and Frontal Lobe With Intraventricular and Subarachnoid Extension in a Triplet Pregnancy Following In Vitro Fertilization: A Case Report and Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Triplet births, particularly those achieved by assisted reproductive technologies, entail markedly elevated maternal and fetal risks, including hypertensive diseases. Intracerebral hemorrhage is an uncommon but devastating complication during the postpartum period.
Raman Goit, Prakash Gupta, Linh Nguyen, Shachi Patel, Karan Kumar Rana, Suman Jaiswal, Prateeti Bekoju, Ranju Shrestha, Daniel Nguyen   +8 more
wiley   +1 more source

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cerebrovascular amyloid-β deposition is highly implicated in the pathogenesis of cerebral amyloid angiopathy (CAA), one of the major causes of dementia.
Takayuki Inoue, S. Saito, Masashi Tanaka, H. Yamakage, T. Kusakabe, A. Shimatsu, M. Ihara, N. Satoh‐Asahara   +7 more
semanticscholar   +1 more source