Results 11 to 20 of about 42,785 (261)

Chronic Stress Exacerbates Cerebral Amyloid Angiopathy Through Promoting Neutrophil Extracellular Traps Formation

Advanced Science
Cerebral amyloid angiopathy (CAA) is the leading cause of vascular dementia among the elderly. Neuropsychiatric symptoms are commonly manifested in cerebral amyloid angiopathy patients but are usually considered as consequences of cerebral amyloid ...
Huipeng Huang, Xiaohui Deng, Yuge Wang, Shishi Shen, Shisi Wang, Mengyan Hu, Sanxin Liu, Xiaotao Su, Chunyi Li, Tiemei Li, Zhengqi Lu, Wei Cai   +11 more
doaj   +2 more sources

Cerebral amyloid angiopathy-related inflammation: current status and future implications

Chinese Medical Journal, 2021
. Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare but increasingly recognized subtype of CAA. CAA-RI consists of two subtypes: inflammatory cerebral amyloid angiopathy and amyloid β (Aβ)-related angiitis.
Juan-Juan Wu, Ming Yao, Jun Ni, Xiu-Yuan Hao   +3 more
doaj   +2 more sources

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Nature Communications, 2023
Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood brain barrier (BBB) integrity in cerebral amyloid angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced
M. Hu, Tiemei Li, Xiaomeng Ma, Sanxin Liu, Chunyi Li, Zhenchao Huang, Yinyao Lin, Ruizhen Wu, Shisi Wang, Danli Lu, T. Lu, X. Men, Shishi Shen, Huipeng Huang, Yuxin Liu, K. Song, Banghao Jian, Yuxuan Jiang, W. Qiu, Quentin Liu, Zhengqi Lu, W. Cai   +21 more
semanticscholar   +1 more source

Clinical considerations in early-onset cerebral amyloid angiopathy

Brain : a journal of neurology, 2023
Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease associated with brain haemorrhage and cognitive change. The commonest form, sporadic amyloid-β CAA, usually affects people in mid- to later life.
G. Banerjee, J. Collinge, Nick C Fox, T. Lashley, S. Mead, J. Schott, D. Werring, N. Ryan   +7 more
semanticscholar   +1 more source

Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy

bioRxiv, 2023
We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy.
Yang Yang, A. Murzin, Sew Y. Peak-Chew, Catarina Franco, Kathy L. Newell, B. Ghetti, Michel Goedert, S. Scheres   +7 more
semanticscholar   +1 more source

Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon

Journal of Neurology Neurosurgery & Psychiatry, 2022
In the last 6 years, following the first pathological description of presumed amyloid-beta (Aβ) transmission in humans (in 2015) and subsequent experimental confirmation (in 2018), clinical cases of iatrogenic cerebral amyloid angiopathy (CAA)—attributed
G. Banerjee, K. Samra, M. Adams, Z. Jaunmuktane, A. Parry-Jones, J. Grieve, A. Toma, S. Farmer, R. Sylvester, H. Houlden, P. Rudge, S. Mead, S. Brandner, J. Schott, J. Collinge, D. Werring   +15 more
semanticscholar   +1 more source

Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy

Brain Communications, 2023
Integrating cerebrospinal fluid-biomarkers into diagnostic workup of patients with sporadic cerebral amyloid angiopathy may support early and correct identification.
J. Sembill, Christoph Lusse, M. Linnerbauer, M. Sprügel, Anne Mrochen, Michael Knott, T. Engelhorn, M. Schmidt, A. Doerfler, T. Oberstein, J. Maler, J. Kornhuber, P. Lewczuk, Veit Rothhammer, S. Schwab, J. Kuramatsu   +15 more
semanticscholar   +1 more source

Sialylation patterns in cerebral amyloid angiopathy. [PDF]

Brain Pathol
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Fastenau C, Crisp R, Keating M, Ochoa E, Richardson TE, Flanagan ME, Walker JM, Hopp SC, Bieniek KF.   +8 more
europepmc   +2 more sources

Inflammatory Cerebral Amyloid Angiopathy: A Broad Clinical Spectrum

Journal of Clinical Neurology, 2023
Cerebral amyloid angiopathy (CAA) is a common central nervous system (CNS) vasculopathy, which in some cases is associated with subacute encephalopathy, seizures, headaches, or strokes due to vascular inflammation directed against vascular amyloid ...
A. de Souza, Kate Tasker
semanticscholar   +1 more source

Prevalence of cerebral amyloid angiopathy: A systematic review and meta‐analysis

Alzheimer's & Dementia, 2021
Reported prevalence estimates of sporadic cerebral amyloid angiopathy (CAA) vary widely. CAA is associated with cognitive dysfunction and intracerebral hemorrhage, and linked to immunotherapy‐related side‐effects in Alzheimer's disease (AD).
Lieke Jäkel, Anna M. de Kort, C. Klijn, F. Schreuder, M. Verbeek   +4 more
semanticscholar   +1 more source