Results 51 to 60 of about 5,618,586 (305)

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

Frontiers in Cellular Neuroscience
IntroductionCerebral edema is a hallmark of lesion progression after acute ischemic stroke (AIS) and a major contributor to the evolution of spreading depolarizations (SDs). SDs trigger extracellular glutamate accumulation and excitotoxic injury, yet the
Rita Frank, Rita Frank, Stephane Marinesco, Ferenc Bari, Ákos Menyhárt, Ákos Menyhárt, Eszter Farkas, Eszter Farkas   +7 more
doaj   +1 more source

Relationship between oxygen supply and cerebral blood flow assessed by transcranial Doppler and near-infrared spectroscopy in healthy subjects during breath-holding [PDF]

, 2006
Background Breath – holding (BH) is a suitable method for inducing cerebral vasomotor reactivity (VMR). The assessment of VMR is of clinical importance for the early detection of risk conditions and for the follow-up of disabled patients.
LIBONI W, Molinari, Filippo, Negri, E., GRIPPI G, NEGRI E., Negri Emanuela, Molinari Filippo, Liboni, W., Grippi Gianfranco, Liboni William, Grippi, G.   +10 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

EEG and cerebral blood flow in newborns during quiet sleep

, 2008
Cerebral blood flow (CBF) alterations in the newborns (NB) can lead to brain damage by adecrease in the supply of oxygen and glucose. Aiming at contributing to an understanding of themechanisms involved, the association between the EEG (right front ...
Maldonado Arango, M.I., Infantosi, A.F.C., Simpson, D.M., Botero Rosas, D.A.   +3 more
core   +1 more source

Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy [PDF]

, 2007
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the ...
Tachtsidis, I, Tachtsidis, I., Delpy, D., Tisdall, M, Leung, T., Smith, M., Elwell, CE, Elwell, C., Delpy, DT, Tisdall, M., Leung, TS, Smith, M   +11 more
core  

Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial [PDF]

, 2016
Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity.
Jackson, Philippa A., Sarah Dunn (3444305), Dunn, Sarah, Philippa Jackson (3444317), Philippa A. Jackson, Jackson, Philippa, Karl Wishart, Fiona L. Dodd, Gregor Bieri (3444302), Alexandra Carne (3444308), David O. Kennedy, Crystal F. Haskell-Ramsay, Stevenson, Emma J., Wishart, Karl, Emma J. Stevenson, Emma Stevenson (649191), Forster, Joanne, Fiona Dodd (3444311), Crystal Haskell-Ramsay (3444314), Sarah Dunn, Haskell, Crystal, Stevenson, Emma, Dodd, Fiona, Kennedy, David O., David Kennedy (91996), Kennedy, David, Luca Barella, Karl Wishart (2299858), Dodd, Fiona L., Luca Barella (3444299), Bieri, Gregor, Robertson, Bernadette, Haskell-Ramsay, Crystal F., Bernadette C. Robertson, Joanne Forster, Carne, Alexandra, Bernadette Robertson (3444323), Gregor Bieri, Barella, Luca, Alexandra Carne, Robertson, Bernadette C., Joanne Forster (3444320)   +41 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Electric muscle stimulation attenuates neuroinflammation and improves the outcome of acute ischemic stroke in mice

Neurotherapeutics
Acute ischemic stroke is a major cause of death and disability, yet many patients cannot engage in early rehabilitation due to severe motor deficits. Resulting immobility accelerates muscle atrophy and systemic inflammation, highlighting muscle–brain ...
Anna Törteli, Péter Kozák, Hiroyuki Uno, Rajmund Hősi, Zsófia Ruppert, Eszter Gáspár, Ferenc Bari, Zsolt Török, Eszter Farkas, Melinda E. Tóth, Ákos Menyhárt   +10 more
doaj   +1 more source

Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation [PDF]

, 2015
Nitrate derived from vegetables is consumed as part of a normal diet and is reduced endogenously via nitrite to nitric oxide. It has been shown to improve endothelial function, reduce blood pressure and the oxygen cost of sub-maximal exercise, and ...
Haskell, Crystal, Winyard, Paul, Kennedy, David, Blackwell, Jamie, Blackwell, James, Thompson, Kevin, Wightman, Emma, Forster, Joanne, Jones, Andrew, Haskell-Ramsay, Crystal   +9 more
core   +1 more source