Results 61 to 70 of about 613,500 (197)

Postzygotic mosaicism in cerebral cavernous malformation [PDF]

Journal of Medical Genetics, 2019
Background Cerebral cavernous malformations (CCMs) can cause severe neurological morbidity but our understanding of the mechanisms that drive CCM formation and growth is still incomplete. Recent experimental data suggest that dysfunctional CCM3-deficient endothelial cell clones form cavernous lesions in ...
Rath, M., Pagenstecher, Axel, Hoischen, A., Hoischen, A., Felbor, U.   +4 more
openaire   +3 more sources

Supplemental materials for a systematic review of stereotactic radiosurgery for cerebral cavernous malformations

, 2019
Supplementary data in support of manuscript: "Stereotactic radiosurgery for cerebral cavernous malformations: a systematic review"
Poorthuis, Michiel, Rinkel, Leon
core   +1 more source

Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling [PDF]

, 2013
Cerebral cavernous malformation (CCM) involves the homozygous inactivating mutations of one of three genes, ccm1, -2, or -3 resulting in hyperpermeable blood vessels in the brain.
Borikova, Asya L., Johnson, Gary L., Dibblel, Christopher F., Richardson, Bryan T.   +3 more
core   +1 more source

YAP Fuels Cerebral Cavernous Malformations by Regulating KLF4 Transcriptional Activity and Protein Stability

MedComm, Volume 7, Issue 11, November 2026.
Cerebral cavernous malformation (CCM) gene complex deficiency dual‐regulates YAP activity via a “dual‐pronged” mechanism: relieving LATS‐mediated inhibition to license YAP nuclear translocation, and promoting MAP3K3‐mediated YAP phosphorylation to stabilize YAP–KLF4 association.
Tingting Ye, Qi Zheng, Zonghao Hu, Haonan Fan, Zhongxing Sun, Xiya Li, Haomin Mo, Chengdong Chang, Yanhua Xu, Kai Wang, Dong Fang, Hai Song   +11 more
wiley   +1 more source

Combination of multiple cerebral cavernous malformations with a falx meningioma: A clinical case

Кубанский научный медицинский вестник
Introduction. Cerebral cavernous malformations may coexist with various disorders of the central nervous system, including brain tumors. There are few descriptions of combined cavernous malformations and meningiomas in the literature.
L. V. Shagal, A. R. Eremyan, A. I. Berdnik, G. R. Obivalina, G. G. Muzlaev   +4 more
doaj   +1 more source

Remarkable Clinical Improvement Following Microsurgical Resection of Left Lingual Gyrus Cerebral Cavernous Malformation: A Case Report

Brazilian Neurosurgery, 2021
Introduction Cerebral cavernous malformations (CCMs) are collections of dilated and irregular capillaries in the brain. Cerebral cavernous malformations are predominantly supratentorial; occipital CCMs are rare.
Samer S. Hoz, Zahraa F. Al-Sharshahi, Mustafa M. Altaweel, Saja A. Albanaa   +3 more
doaj   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, Volume 36, Issue 6, November 2026.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

CEREBRAL CAVERNOUS MALFORMATION COEXISTING WITH PITUITARY ADENOMA, HASHIMOTO THYROIDITIS AND MENTAL ILLNESS: FIRST CASE REPORT.

, 2017
Cerebral Cavernous Malformations (CCMs) are vascular lesions involving brain capillaries. They may occur sporadically or be inherited as autosomal dominant character.
Sara Guido
core   +1 more source

Vascular Permeability in Cerebral Cavernous Malformations [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo.
Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik B W, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A   +13 more
openaire   +3 more sources

Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease

AGING MEDICINE, Volume 9, Issue 5, Page 464-471, October 2026.
Among 132 older adults, 13 had peripheral artery disease (PAD), identified using the ankle–brachial index. Over approximately 13 months, PAD was associated with increasing middle cerebral artery mean flow velocity, with a significant difference in left‐sided velocity change between groups.
SangMi Noh, Hae‐Eun Shin, YongSoo Shim
wiley   +1 more source