Results 71 to 80 of about 6,027 (196)

Stroke‐Mimic: An Intracranial Dural Arteriovenous Fistula Revealed by New‐Onset Seizures and Post‐Ictal Deficit

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Intracranial dural arteriovenous fistulas (iDAVFs) are rare vascular malformations with diverse neurological symptoms depending on their venous drainage pattern. We describe a 59‐year‐old man who presented with transient right‐sided weakness and facial droop following new‐onset seizures. CT demonstrated asymmetric arterial‐phase enhancement of
Michael Van Haute, Mary Martin, Mark Harmon   +2 more
wiley   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Vascular Permeability in Cerebral Cavernous Malformations [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo.
Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik B W, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A   +13 more
openaire   +3 more sources

Cerebral cavernous malformation presenting as seizures

, 2020
Cerebral cavernous malformations (CCMs) is one of the rare vascular malformation. It is diagnosed by characteristic lesions on magnetic resonance imaging (MRI).
Farooq, Ayisha, Mairaj Khan, Muhammad, Brohi, Hazim, Rehan, Bushra   +3 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth

, 2018
Rationale: The clinical course of cerebral cavernous malformations is highly unpredictable, with few cross-sectional studies correlating proinflammatory genotypes and plasma biomarkers with prior ...
Dean Y. Li, Sean Polster, Kiranj Chaudagar, David Leclerc, Hussein A. Zeineddine, Kevin J. Whitehead, Maged D. Fam, Changbin Shi, Robert Shenkar, Ryan Duggan, Rhonda Lightle, Romuald Girard, Issam A. Awad, Ying Cao, Thomas Moore, Agnieszka Stadnik, Janne Koskimäki   +16 more
core   +1 more source

Intracranial meningioma and concomitant cavernous malformation: a series description and review of the literature

, 2020
Objectives: Intracranial meningioma with concomitant cavernous malformation has been rarely described in the literature. This study aimed to investigate the correct neurosurgical conduct.
Sergio Paolini, Massimo Vigliotta, Paolo Missori, Angela Ambrosone, Cristina Mancarella, Stefano Martini, Simone Peschillo, Emanuela Rastelli   +7 more
core   +1 more source

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature Communications, 2019
Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of ...
Matteo Malinverno, Claudio Maderna, Abdallah Abu Taha, Monica Corada, Fabrizio Orsenigo, Mariaelena Valentino, Federica Pisati, Carmela Fusco, Paolo Graziano, Monica Giannotta, Qing Cissy Yu, Yi Arial Zeng, Maria Grazia Lampugnani, Peetra U. Magnusson, Elisabetta Dejana   +14 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Cerebral cavernous malformation proteins at a glance [PDF]

Journal of Cell Science, 2014
Loss-of-function mutations in genes encoding KRIT1 (also known as CCM1), CCM2 (also known as OSM and malcavernin) or PDCD10 (also known as CCM3) cause cerebral cavernous malformations (CCMs). These abnormalities are characterized by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal ...
Kyle M, Draheim, Oriana S, Fisher, Titus J, Boggon, David A, Calderwood   +3 more
openaire   +2 more sources