Results 91 to 100 of about 4,624 (210)

Loss of cerebral cavernous malformation 3 ( Ccm3 ) in neuroglia leads to CCM and vascular pathology [PDF]

Proceedings of the National Academy of Sciences, 2011
Communication between neural cells and the vasculature is integral to the proper development and later function of the central nervous system. A mechanistic understanding of the interactions between components of the neurovascular unit has implications for various disorders, including cerebral cavernous malformations (CCMs) in ...
Angeliki, Louvi, Leiling, Chen, Aimee M, Two, Haifeng, Zhang, Wang, Min, Murat, Günel   +5 more
openaire   +2 more sources

Subclinical rhythmic EEG discharge of adults (SREDA) in pediatric population: A case series with systematic review of the literature

Epileptic Disorders, Volume 27, Issue 1, Page 71-81, February 2025.
Abstract Subclinical rhythmic electrographic discharge of adults (SREDA) is one of the rarest and most challenging non‐epileptic electroencephalographic variants. Although the pathogenesis of this activity is unclear, an association with vascular insufficiency and cerebral hypoxia has been proposed.
Luca Bosisio, Maria Margherita Mancardi, Silvia Boeri, Lino Nobili, Giulia Nobile, Laura Siri, Giulia Prato, Edoardo Canale   +7 more
wiley   +1 more source

Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease

Biomedicines, 2023
Cerebral cavernous malformation (CCM) or cavernoma is a major vascular disease of genetic origin, whose main phenotypes occur in the central nervous system, and is currently devoid of pharmacological therapeutic strategies.
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta   +7 more
doaj   +1 more source

Genetic Insights Into Coronary Microvascular Disease

Microcirculation, Volume 32, Issue 1, January 2025.
ABSTRACT Coronary microvascular disease (CMVD) affects the coronary pre‐arterioles, arterioles, and capillaries and can lead to blood supply–demand mismatch and cardiac ischemia. CMVD can present clinically as ischemia or myocardial infarction with no obstructive coronary arteries (INOCA or MINOCA, respectively). Currently, therapeutic options for CMVD
Nicole Wayne, Venkata S. Singamneni, Rasika Venkatesh, Tess Cherlin, Shefali S. Verma, Marie A. Guerraty   +5 more
wiley   +1 more source

A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms

Scientific Reports, 2021
Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches.
Hilal Eren Gozel, Kıvanç Kök, Fatma Ozlen, Cihan Isler, Sadrettin Pence   +4 more
doaj   +1 more source

Inherited cavernous malformations of the central nervous system: clinical and genetic features in 19 Swiss families [PDF]

, 2018
Cavernous malformations (CCMs) are benign, well-circumscribed, and mulberry-like vascular malformations that may be found in the central nervous system in up to 0.5% of the population. Cavernous malformations can be sporadic or inherited.
Andermann, F., Baumann, C., Baumgartner, R., Bonassin, F., Georgiadis, D., Graeni, C., Merlo, A., Rouleau, G., Siegel, A., Stepper, F., Sturzenegger, M., Verlaan, D.   +11 more
core  

Cerebral vascular malformations: pathogenesis and therapy

MedComm, Volume 5, Issue 12, December 2024.
CVMs management based on imaging genomics and liquid biopsy. In the future, somatic or de novo germline mutation information could be used to direct neurosurgical and medical management of CVMs. Somatic or germline variants can be acquired from imaging genomics or liquid biopsies preoperatively.
Qiheng He, Ran Huo, Yingfan Sun, Zhiyao Zheng, Hongyuan Xu, Shaozhi Zhao, Yang Ni, Qifeng Yu, Yuming Jiao, Wenqian Zhang, Jizong Zhao, Yong Cao   +11 more
wiley   +1 more source

Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation [PDF]

, 2021
Cerebral cavernous malformations (CCMs) are neurovascular abnormalities characterized by thin, leaky blood vessels resulting in lesions that predispose to hemorrhages, stroke, epilepsy, and focal neurological deficits.
Su, Valerie L
core   +1 more source

Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine

MedComm, Volume 5, Issue 10, October 2024.
Four main applications of organoids. The main applications of organoids include the construction of disease models, drug screening and toxicity evaluation, precision medicine, and regenerative medicine. Abstract Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions of specific organs ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Guoqiang Cao, Lanjuan Li, Hongcui Cao   +6 more
wiley   +1 more source

Ethanol-Induced Alterations in Placental and Fetal Cerebrocortical Annexin-A4 and Cerebral Cavernous Malformation Protein 3 Are Associated With Reductions in Fetal Cortical VEGF Receptor Binding and Microvascular Density

Frontiers in Neuroscience, 2020
Jegou et al. (2012) have reported prenatal alcohol exposure (PAE)-induced reductions of angiogenesis-related proteins in mouse placenta. These effects were associated with striking alterations in microvascular development in neonatal cerebral cortex ...
Daniel D. Savage, Martina J. Rosenberg, Laurent Coquet, Morgan W. Porch, Nyika A. Allen, Christian Roux, Caroline Aligny, Thierry Jouenne, Bruno J. Gonzalez   +8 more
doaj   +1 more source