Results 101 to 110 of about 1,916 (204)

MEKK3 bridges gut-brain communication and cerebral cavernous malformation pathogenesis

Cell Death Discovery
Cerebral cavernous malformation (CCM) is a condition affecting the brain vasculature, characterized by endothelial dysfunction and abnormal vascular structure. In recent years, the gut-brain axis has emerged as a significant regulatory factor influencing
Peng Cheng, Hongkuan Han, Ying Huang, Yang Shen, Xuan Jiang, Xiaoxiong Song, Cheng Qian, Lei Chen, Yang Zhao   +8 more
doaj   +1 more source

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Cell Reports
Summary: Cerebral cavernous malformation (CCM) is a neurovascular disease distinguished by clusters of leaky, mulberry-like blood vessels. KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; however ...
Maximiliano Arce, Iza Erzar, Fan Yang, Neeharika Senthilkumar, Favour C. Onyeogaziri, Dario Ronchi, Frida C. Ahlstrand, Nora Noll, Roberta Lugano, Mark Richards, Elisa Scola, Monica Corada, Francesca Lazzaroni, Linda Meggiolaro, Jens Schuster, Niklas Dahl, Mika Niemelä, Behnam Rezai Jahromi, Anna Dimberg, Silvia Lanfraconi, Roberto Latini, Peetra U. Magnusson   +21 more
doaj   +1 more source

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Doctor of Philosophy [PDF]

, 2011
dissertationCerebral cavernous malformation (CCM), or cavernous angioma, is a common disease that can occur sporadically or familially with autosomal dominant inheritance. CCMs are vascular malformations, predominantly in the brain, consisting of dilated,
Chan, Aubrey C.
core  

Cerebral cavernous malformation with prolonged postoperative paralysis due to perilesional inflammation: illustrative case [PDF]

BACKGROUND: Postoperative symptom exacerbation after resection of cerebral cavernous malformations (CCMs) is usually due to surgical damage to the eloquent areas or venous outflow obstruction from injury to a developmental venous anomaly (DVA ...
Arakawa, Yoshiki, Hattori, Etsuko Yamamoto, Inai, Soichi, Makino, Yasuhide, Mineharu, Yohei, Sano, Noritaka, Takada, Shigeki, Takeuchi, Yasuhide, Tanji, Masahiro   +8 more
core   +1 more source

Case report: A second case of cerebral cavernous malformation after high-dose chemotherapy for medulloblastoma

Frontiers in Oncology
The development of cerebral cavernous malformations (CCMs) is a well-recognized sequela of irradiation to the brain in pediatric tumors, particularly in medulloblastoma, glioma, and acute lymphoblastic leukaemia.
Maria Grazia Pionelli, Federica Mazio, Maria Elena Errico, Carmela Russo, Adriana Cristofano, Eugenio Maria Covelli, Vittoria Donofrio, Maria Capasso, Michele Antonio Capozza, Fabiola De Gregorio, Serena Ruotolo, Massimo Eraldo Abate, Giuseppe Cinalli   +12 more
doaj   +1 more source

Hemorrhagic Brainstem Cavernous Malformation : An Uncommon Cause of Multiple Cranial Nerve Palsies in an ENT Evaluation

Health Research in Africa
Multiple cranial nerve palsies represent a diagnostic challenge in ENT consultations due to the diversity of possible etiologies. We describe an extremely rare cause of multiple cranial nerve lesions: cerebral cavernous malformation (CCM) hemorrhage of ...
Ngo Nyeki Adèle-Rose, Ngarka Leonard, Mossus Yannick, Nganso Tatiana, Mboua Veronique, Meva'a Roger, Atanga Léonel, Ngaba Mambo Olive, Nfor Leonard, Mindja David, Djomou Francois, Njamnshi Alfred, Njock Richard   +12 more
doaj   +1 more source

Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing

Computational and Structural Biotechnology Journal
Cerebral cavernous malformation (CCM) is a polygenic disease with intricate genetic interactions contributing to quantitative pathogenesis across multiple factors.
Yiqi Wang, Jinmei Zuo, Chao Duan, Hao Peng, Jia Huang, Liang Zhao, Li Zhang, Zhiqiang Dong   +7 more
doaj   +1 more source

Biology of vascular malformations of the brain [PDF]

, 2009
,, Al-Shahi Salman, Rustam, Awad, Issam A, Golanov, Eugene, Leblanc, Gabrielle G, Young, William L   +5 more
core   +1 more source

Improved differentiation of cavernous malformation and acute intraparenchymal hemorrhage on CT using an AI algorithm

Scientific Reports
This study aimed to evaluate the utility of an artificial intelligence (AI) algorithm in differentiating between cerebral cavernous malformation (CCM) and acute intraparenchymal hemorrhage (AIH) on brain computed tomography (CT).
Jung Youn Kim, Hye Jeong Choi, Sang Heum Kim, Hwangseon Ju   +3 more
doaj   +1 more source