Results 81 to 90 of about 1,916 (204)

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source

Circulating Blood Prognostic Biomarker Signatures for Hemorrhagic Cerebral Cavernous Malformations (CCMs)

International Journal of Molecular Sciences
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic strokes, a major cause of death and disability worldwide. The limited treatment options for CCMs underscore the importance of prognostic biomarkers to predict the likelihood of
Jacob Croft, Brian Grajeda, Luis A. Aguirre, Johnathan S. Abou-Fadel, Cameron C. Ellis, Igor Estevao, Igor C. Almeida, Jun Zhang   +7 more
openaire   +2 more sources

Subclinical rhythmic EEG discharge of adults (SREDA) in pediatric population: A case series with systematic review of the literature

Epileptic Disorders, Volume 27, Issue 1, Page 71-81, February 2025.
Abstract Subclinical rhythmic electrographic discharge of adults (SREDA) is one of the rarest and most challenging non‐epileptic electroencephalographic variants. Although the pathogenesis of this activity is unclear, an association with vascular insufficiency and cerebral hypoxia has been proposed.
Luca Bosisio, Maria Margherita Mancardi, Silvia Boeri, Lino Nobili, Giulia Nobile, Laura Siri, Giulia Prato, Edoardo Canale   +7 more
wiley   +1 more source

Cerebral Cavernous Malformations: An Update on Prevalence, Molecular Genetic Analyses, and Genetic Counselling [PDF]

, 2018
Based on the latest gnomAD dataset, the prevalence of symptomatic hereditary cerebral cavernous malformations (CCMs) prone to cause epileptic seizures and stroke-like symptoms was re-evaluated in this review and calculated to be 1:5,400-1:6,200 ...
Felbor, Ute, Paperlein, Christin, Rath, Matthias, Spiegler, Stefanie   +3 more
core   +1 more source

A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms

Scientific Reports, 2021
Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches.
Hilal Eren Gozel, Kıvanç Kök, Fatma Ozlen, Cihan Isler, Sadrettin Pence   +4 more
doaj   +1 more source

Genetic Insights Into Coronary Microvascular Disease

Microcirculation, Volume 32, Issue 1, January 2025.
ABSTRACT Coronary microvascular disease (CMVD) affects the coronary pre‐arterioles, arterioles, and capillaries and can lead to blood supply–demand mismatch and cardiac ischemia. CMVD can present clinically as ischemia or myocardial infarction with no obstructive coronary arteries (INOCA or MINOCA, respectively). Currently, therapeutic options for CMVD
Nicole Wayne, Venkata S. Singamneni, Rasika Venkatesh, Tess Cherlin, Shefali S. Verma, Marie A. Guerraty   +5 more
wiley   +1 more source

Cerebral vascular malformations: pathogenesis and therapy

MedComm, Volume 5, Issue 12, December 2024.
CVMs management based on imaging genomics and liquid biopsy. In the future, somatic or de novo germline mutation information could be used to direct neurosurgical and medical management of CVMs. Somatic or germline variants can be acquired from imaging genomics or liquid biopsies preoperatively.
Qiheng He, Ran Huo, Yingfan Sun, Zhiyao Zheng, Hongyuan Xu, Shaozhi Zhao, Yang Ni, Qifeng Yu, Yuming Jiao, Wenqian Zhang, Jizong Zhao, Yong Cao   +11 more
wiley   +1 more source

Ethanol-Induced Alterations in Placental and Fetal Cerebrocortical Annexin-A4 and Cerebral Cavernous Malformation Protein 3 Are Associated With Reductions in Fetal Cortical VEGF Receptor Binding and Microvascular Density

Frontiers in Neuroscience, 2020
Jegou et al. (2012) have reported prenatal alcohol exposure (PAE)-induced reductions of angiogenesis-related proteins in mouse placenta. These effects were associated with striking alterations in microvascular development in neonatal cerebral cortex ...
Daniel D. Savage, Martina J. Rosenberg, Laurent Coquet, Morgan W. Porch, Nyika A. Allen, Christian Roux, Caroline Aligny, Thierry Jouenne, Bruno J. Gonzalez   +8 more
doaj   +1 more source

Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine

MedComm, Volume 5, Issue 10, October 2024.
Four main applications of organoids. The main applications of organoids include the construction of disease models, drug screening and toxicity evaluation, precision medicine, and regenerative medicine. Abstract Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions of specific organs ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Guoqiang Cao, Lanjuan Li, Hongcui Cao   +6 more
wiley   +1 more source

Use of balloon angioplasty for patients with intracranial large atherosclerotic acute ischemic stroke and cerebral cavernous malformation: a case report

Frontiers in Neurology
Thus far, clinical data relating to the treatment of cerebral cavernous malformation (CCM) patients with acute stroke (AIS) are incredibly scare due to the low incidence of CCM.
Yiwan Wang, Tianyu Wang, Jiangmin Liang
doaj   +1 more source