Results 101 to 110 of about 4,624 (210)

Venous Malformations in Childhood: Clinical, Histopathological and Genetics Update [PDF]

, 2021
Our knowledge in vascular anomalies has grown tremendously in the past decade with the identification of key molecular pathways and genetic mutations that drive the development of vascular tumors and vascular malformations.
Colmenero, Isabel, Knöpfel, Nicole
core  

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. [PDF]

, 2020
Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery.
Chen J, Choi J, Cogger VC, Coleman P, Gamble JR, Li J, Moller T, Shi Z, Ting KK, Vadas MA, Wan L, Zhao Y, Zheng X   +12 more
core   +1 more source

Markov models for clinical decision‐making in radiation oncology: A systematic review

Journal of Medical Imaging and Radiation Oncology, Volume 68, Issue 5, Page 610-623, August 2024.
Abstract The intrinsic stochasticity of patients' response to treatment is a major consideration for clinical decision‐making in radiation therapy. Markov models are powerful tools to capture this stochasticity and render effective treatment decisions.
Lucas B McCullum, Aysenur Karagoz, Cem Dede, Raul Garcia, Fatemeh Nosrat, Mehdi Hemmati, Seyedmohammadhossein Hosseinian, Andrew J Schaefer, Clifton D Fuller, on behalf of the Rice/MD Anderson Center for Operations Research in Cancer (CORC), MD Anderson Head and Neck Cancer Symptom Working Group   +10 more
wiley   +1 more source

Endothelial cell diversity: the many facets of the crystal

The FEBS Journal, Volume 291, Issue 15, Page 3287-3302, August 2024.
Endothelial cells form the inner lining of blood vessels and play crucial roles in angiogenesis. Recent years have seen a surge in the identification of spatiotemporal molecular and functional heterogeneity of ECs. In this review, we highlight many aspects of the diversity of ECs, such as their morphological heterogeneity, the paracrine release of ...
Lorena Perez‐Gutierrez, Pin Li, Napoleone Ferrara   +2 more
wiley   +1 more source

Genetic mutations and phenotype characteristics in peripheral vascular malformations: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 38, Issue 7, Page 1314-1328, July 2024.
Abstract Vascular malformations (VMs) are clinically diverse with regard to the vessel type, anatomical location, tissue involvement and size. Consequently, symptoms and disease impact differ significantly. Diverse causative mutations in more and more genes are discovered and play a major role in the development of VMs.
M. L. E. Stor, S. E. R. Horbach, M. M. Lokhorst, E. Tan, S. M. Maas, C. J. M. van Noesel, C. M. A. M. van der Horst   +6 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line (UNCCi002-A) from a healthy donor using a non-integration system to study Cerebral Cavernous Malformation (CCM).

Stem Cell Research, 2021
Alvaro A. Beltran, Sarahi G Molina, Ariana B. Marquez, Lorena J Munoz, José F. Olivares, Adriana S. Beltran   +5 more
semanticscholar   +1 more source

Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies

Pharmacology Research &Perspectives, Volume 12, Issue 3, June 2024.
Cerebral cavernous malformation (CCM) pathogenesis involves elevated reactive oxygen species (ROS) levels. REC‐994 restores ROS balance, and in double‐blind, placebo‐controlled, trials in healthy volunteers, had low potential for off‐target adverse effects and pharmacokinetics suitable for phase 2 development.
Ron Alfa, Timothy Considine, Shafique Virani, Matt Pfeiffer, Anthony Donato, Daniel Dickerson, Diana Shuster, Joel Ellis, Kristen Rushton, Helen Wei, Christopher Gibson   +10 more
wiley   +1 more source

Angiopoietin-2 predicts morbidity in adults with Fontan physiology. [PDF]

, 2019
Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, and pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications.
Aboulhosn, Jamil A, Boström, Kristina I, Conrad, Miles B, Guihard, Pierre J, Iruela-Arispe, M Luisa, Kim, Helen, Lluri, Gentian, Pawlikowska, Ludmila, Shirali, Aditya S   +8 more
core  

Cerebral Cavernous Malformations: An Update on Prevalence, Molecular Genetic Analyses, and Genetic Counselling [PDF]

, 2018
Based on the latest gnomAD dataset, the prevalence of symptomatic hereditary cerebral cavernous malformations (CCMs) prone to cause epileptic seizures and stroke-like symptoms was re-evaluated in this review and calculated to be 1:5,400-1:6,200 ...
Felbor, Ute, Paperlein, Christin, Rath, Matthias, Spiegler, Stefanie   +3 more
core   +1 more source

FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations [PDF]

, 2016
Cerebral cavernous malformations (CCMs) are prevalent slow-flow vascular lesions which harbour the risk to develop intracranial haemorrhages, focal neurological deficits, and epileptic seizures.
Acker-Palmer, Amparo, Felbor, Ute, Fischer, Andreas, Gilissen, Christian, Kirchmaier, Bettina, Korenke, G. Christoph, Kuss, Andreas W., Neveling, Kornelia, Rath, Matthias, Schulte-Merker, Stefan, Spiegler, Stefanie, Tetzlaff, Fabian, van de Vorst, Maartje   +12 more
core   +1 more source