Results 111 to 120 of about 4,624 (210)

Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta‐Analysis, and Network Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cerebral cavernous malformations are complex vascular anomalies in the central nervous system associated with a risk of intracranial hemorrhage.
Basel Musmar, Hamza Salim, Jihad Abdelgadir, Samantha Spellicy, Nimer Adeeb, Ali Zomorodi, Allan Friedman, Issam Awad, Pascal M. Jabbour, David M. Hasan   +9 more
doaj   +1 more source

NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation–mediated CCM1/2 expression

The Journal of Clinical Investigation, 2022
The loss function of cerebral cavernous malformation (CCM) genes leads to most CCM lesions characterized by enlarged leaking vascular lesions in the brain.
Zhi Fang, Xiaoran Sun, Xiang Wang, Ji Ma, Thomas Palaia, Ujala Rana, Benjamin Miao, Louis Ragolia, Wenquan Hu, Qing Robert Miao   +9 more
doaj   +1 more source

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Cell Reports
Summary: Cerebral cavernous malformation (CCM) is a neurovascular disease distinguished by clusters of leaky, mulberry-like blood vessels. KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; however ...
Maximiliano Arce, Iza Erzar, Fan Yang, Neeharika Senthilkumar, Favour C. Onyeogaziri, Dario Ronchi, Frida C. Ahlstrand, Nora Noll, Roberta Lugano, Mark Richards, Elisa Scola, Monica Corada, Francesca Lazzaroni, Linda Meggiolaro, Jens Schuster, Niklas Dahl, Mika Niemelä, Behnam Rezai Jahromi, Anna Dimberg, Silvia Lanfraconi, Roberto Latini, Peetra U. Magnusson   +21 more
doaj   +1 more source

Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study

Scientific Reports
Abstract Introduction: Brainstem cerebral cavernous malformations (CCM) are clinically more aggressive compared to superficial CCMs. Due to their location, resection can be challenging, making stereotactic radiosurgery (SRS) an attractive alternative for symptomatic patient.
Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Xu, Zhiyuan, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce, Nabeel, Ahmed, Reda, Wael, Tawadros, Sameh, Abdelkarim, Khaled, El-Shehaby, Amr, Eldin, Reem, Elazzazi, Ahmed, Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald, Alzate, Juan, Kondziolka, Douglas, Bowden, Greg, Patel, Samir, Sheehan, Jason   +35 more
openaire   +4 more sources

Study of the DNA promoter methylation of CCM genes in human cerebral cavernous malformation

, 2019
Objective: CCM is the second most common cerebrovascular disease and is classified as familial (20%) and sporadic (80%) forms. Loss of function mutation of three CCM genes can cause the familial CCM. However, the mechanism causing sporadic CCM remains unclear. Considering the DNA promoter [for full text, please go to the a.m. URL]
Saban, DV, Larisch, J, Nickel, AC, Dammann, P, Sure, U, Zhu, Y   +5 more
openaire   +1 more source

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Cerebral cavernous malformation (CCM) – experience of a specialised cavernoma outpatient clinic with more than 1000 cases

, 2019
70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für ...
Dammann, P, Saban, D, Rauscher, S, Herten, A, Jabbarli, R, Wrede, K, Sure, U   +6 more
openaire   +2 more sources

Creation of a database for evaluating the effect of genetic intellectual property on genetic diagnostic testing [PDF]

, 2006
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.Includes bibliographical references (leaves 33-34).In this study, we explore the impact of gene-based patents on the pricing and availability of genetic ...
Murray, Philip (Philip E.)
core  

Hemorrhagic Brainstem Cavernous Malformation : An Uncommon Cause of Multiple Cranial Nerve Palsies in an ENT Evaluation

Health Research in Africa
Multiple cranial nerve palsies represent a diagnostic challenge in ENT consultations due to the diversity of possible etiologies. We describe an extremely rare cause of multiple cranial nerve lesions: cerebral cavernous malformation (CCM) hemorrhage of ...
Ngo Nyeki Adèle-Rose, Ngarka Leonard, Mossus Yannick, Nganso Tatiana, Mboua Veronique, Meva'a Roger, Atanga Léonel, Ngaba Mambo Olive, Nfor Leonard, Mindja David, Djomou Francois, Njamnshi Alfred, Njock Richard   +12 more
doaj   +1 more source

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

bioRxiv
Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 (CCM1), CCM2, or PDCD10 (CCM3) genes.
Joseph Offenberger, Bianca Chen, Leigh-Ana M. Rossitto, Irisa Jin, Liam Conaboy, H. Gallego-Gutiérrez, Bliss Nelsen, E. Frias-Anaya, David J. Gonzalez, S. Anagnostaras, M. Lopez-Ramirez   +10 more
semanticscholar   +1 more source