Results 81 to 90 of about 4,624 (210)

Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023
Background Familial cerebral cavernous alformation (CCM) is an autosomal dominant disease caused by mutations in KRIT1, CCM2, or PDCD10. Cases typically present with multiple lesions, strong family history, and neurological symptoms, including seizures ...
S. Weinsheimer, J. Nelson, A. Abla, N. Ko, Cynthia Tsang, Obiora C Okoye, J. Zabramski, Amy L Akers, A. Zafar, M. Mabray, B. Hart, L. Morrison, C. McCulloch, Helen Kim   +13 more
semanticscholar   +1 more source

Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study

Stroke and vascular neurology, 2023
Background Cerebral cavernous malformations (CCMs) frequently manifest with haemorrhages. Stereotactic radiosurgery (SRS) has been employed for CCM not suitable for resection. Its effect on reducing haemorrhage risk is still controversial.
C. Dumot, G. Mantziaris, Sam Dayawansa, Zhiyuan Xu, S. Pikis, S. Peker, Y. Samancı, G. Ardor, A. Nabeel, W. Reda, S. Tawadros, K. Abdelkarim, A. El-Shehaby, R. E. Emad Eldin, A. H. Elazzazi, N. M. Moreno, R. Martínez Álvarez, R. Liščák, J. May, D. Mathieu, J. Tourigny, M. Tripathi, A. Rajput, Narendra Kumar, R. Kaur, P. Picozzi, A. Franzini, Herwin Speckter, Wenceslao Hernández, Anderson Brito, R. Warnick, J. Alzate, D. Kondziolka, G. Bowden, Samir Patel, J. Sheehan   +35 more
semanticscholar   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Circulating Blood Prognostic Biomarker Signatures for Hemorrhagic Cerebral Cavernous Malformations (CCMs)

International Journal of Molecular Sciences
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic strokes, a major cause of death and disability worldwide. The limited treatment options for CCMs underscore the importance of prognostic biomarkers to predict the likelihood of
Jacob Croft, Brian Grajeda, Luis A. Aguirre, Johnathan S. Abou-Fadel, Cameron C. Ellis, Igor Estevao, Igor C. Almeida, Jun Zhang   +7 more
openaire   +2 more sources

Familiäre Kavernome des Zentralnervensystems: Eine klinische und genetische Studie an 15 deutsche Familien [PDF]

, 2018
Zusammenfassung: 1928 beschrieb Hugo Friedrich Kufs erstmalig eine Familie mit zerebralen, retinalen und kutanen Kavernomen. Mittlerweile wurden über 300 weitere Familien beschrieben.
Andermann, E., Andermann, F., Baumann, C., Bertalanffy, H., Dichgans, J., Elger, C., Hopf, H., Hopf, N., Keidel, M., Kleider, A., Nowak, G., Pfeiffer, R., Rouleau, G., Schramm, J., Siegel, A., Spuck, S., Stefan, H., Sure, U., Verlaan, D.   +18 more
core  

A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI

Frontiers in Medicine, 2023
AimNeuroinflammation plays a key role in both the pathogenesis and the progression of cerebral cavernous malformations (CCM). Flutriciclamide ([18F]GE-180) is a translocator protein (TSPO) targeting positron emission tomography (PET) tracer, developed ...
Sally Ji Who Kim, Sally Ji Who Kim, Janine M. Lupo, Yicheng Chen, Miguel H. Pampaloni, Henry F. VanBrocklin, Jared Narvid, Helen Kim, Youngho Seo   +8 more
doaj   +1 more source

Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Vesicle trafficking is an essential cellular process that plays an important role in tumour progression. Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape.
Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang, Dan Yue   +10 more
wiley   +1 more source

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source

Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations:a population-based cohort study, systematic review, and meta-analysis [PDF]

, 2019
Background Antithrombotic (anticoagulant or antiplatelet) therapy is withheld from some patients with cerebral cavernous malformations, because of uncertainty around the safety of these drugs in such patients. We aimed to establish whether antithrombotic

core   +3 more sources

Cerebral cavernous malformations (CCM) – the second symptomatic haemorrhage – long-term follow-up

, 2019
Objective: Risk for recurrent symptomatic hemorrhage in CCM is an important factor in decision making/consultation of patients. In this report, we analyze the risk and time pattern of re-hemorrhage events after a first initial bleeding. Methods: We performed a cross-sectional study based on[for full text, please go to the a.m. URL]
Rauscher, S, Herten, A, Saban, DV, Jabbarli, R, Wrede, K, Sure, U, Dammann, P   +6 more
openaire   +2 more sources