Results 171 to 180 of about 634,872 (202)
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Cerebral Cavernous Malformations
New England Journal of Medicine, 2017A 59-year-old man presented with a 1-year history of progressively worsening headaches. Imaging revealed multiple lesions, and genetic analysis confirmed a diagnosis of the familial cerebral cavernous malformation syndrome.
Ithamar, Ganmore, Anat, Achiron
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Evaluating Strategies for the Treatment of Cerebral Cavernous Malformations
Stroke, 2010 Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurological deficits, and potentially fatal hemorrhagic stroke.
Kevin J Whitehead
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Genetics of cerebral cavernous malformations
Current Neurology and Neuroscience Reports, 2005The past few years have seen rapid advances in our understanding of the genetics and molecular biology of cerebral cavernous malformations (CCM). This article summarizes the recent cloning of the CCM1, CCM2, and CCM3 genes, which are responsible for autosomal dominant CCM, and also describes current hypotheses for their roles in integrin and p38 ...
Nicholas W, Plummer +2 more
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Cerebral cavernous malformations
Neurology, 2002To find mutations in the recently identified additional exons of the Krit1 gene that causes CCM1, a disease characterized by the formation of cerebral cavernous malformations (CCM). To determine the relative frequency with which Krit1 mutations cause CCM as well as recharacterize the mutations reported in the literature.Twenty-seven families and 11 ...
D J, Verlaan +5 more
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Cerebral Cavernous Malformations
Archives of Neurology, 1989To the Editor. —In the February 1989 issue of theArchives, Allard et al 1 described several members of a family who had multiple lesions noted on magnetic resonance imaging that were termed arteriovenous malformations . These lesions, however, have the characteristic magnetic resonance imaging appearance of cavernous malformations (angiomas), another ...
K. S. Lee, R. F. Spetzler
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The natural history of cerebral cavernous malformations
Journal of Neurosurgery, 1995✓ To determine the natural history of brain cavernous malformations, the authors entered patients referred to their center into a prospective registry between 1987 and 1993. All patients underwent magnetic resonance imaging, which showed the typical appearance of this lesion, and conservative management was recommended in all.
D, Kondziolka +2 more
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Cerebral Cavernous Malformations (CCM)
2020This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease ...
Lorenza Trabalzini +2 more
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Radiation-induced cerebral cavernous malformations
Journal of the Neurological SciencesCerebral cavernous malformations (CCMs) are hamartomatous vascular lesions. A part of CCMs is estimated to occur after cranial irradiation. However, there have been no reports documenting clinical picture of such CCMs. This study aimed to explore it.A total of 51 patients with multiple CCMs who visited our hospital, between 2006 and 2024, were explored.
Satoshi, Tsutsumi +5 more
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Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations
New England Journal of Medicine, 2021Franck Bielle +2 more
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