Results 41 to 50 of about 634,872 (202)

A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation [PDF]

, 2022
Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation.
Akagawa, Hiroyuki, Sasaki, Tatsuya, Hiroyuki Akagawa, Nakano, Yumiko, Taijun Yunoki, Koji Abe, Yamashita, Toru, Omote, Yoshio, Mami Takemoto, Yumiko Nakano, Nozomi Hishikawa, Emi Nomura, Nomura, Emi, Yunoki, Taijun, Tatsuya Sasaki, Morihara, Ryuta, Toru Yamashita, Takemoto, Mami, Ryuta Morihara, Yoshio Omote, Hishikawa, Nozomi, Abe, Koji   +21 more
core   +1 more source

Multiple supratentorial and infratentorial cavernous malformations

, 2008
WOS: 000256162100013Although cerebral cavernous malformations can be encountered through the entire central nervous system, they are frequently seen in the cerebral hemispheres.
Deniz Yerdelen, Zafer Koc, Filiz Koc, Koc Z., Yerdelen D., Koc F.   +5 more
core   +2 more sources

The Role of Intraoperative Neurophysiological Monitoring in Intracranial Cavernous Malformation Surgery: A Narrative Review [PDF]

Iranian Journal of Medical Sciences
Cavernous malformations, also known as cavernous hemangiomas or cavernomas, are abnormal vascular lesions that can occur in various parts of the body, including intracranially.
Mei Shao, Qi-Yang Huai, Jian-Wei Song, Fu-Qiang Wang, Yan-Na Li, Xia Li, Feng-Ling Wang   +6 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Natural History, Clinical, and Surgical Management of Cavernous Malformations

, 2020
We describe Natural history, clinical and surgical management of cavernous malformation of the brain and spinal cord. Decision-making for treatment of cavernous malformations cannot ignore their natural history and risk of bleeding, which is different ...
Filippo Veneziani Santonio, Vercelli, Giovanni G, Cofano, Fabio, Vincitorio, Francesca, Santonio, Filippo Veneziani, Zenga, Francesco, Francesca Vincitorio, Garbossa, Diego, Diego Garbossa, Francesco Zenga, Giovanni G. Vercelli, Fabio Cofano   +11 more
core   +1 more source

Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view [PDF]

, 2016
A growing amount of evidence indicates that autophagy plays a pivotal role in a plethora of human pathological conditions. We have recently broadened the list of the so-called autophagy-related diseases, describing the involvement of defective autophagy ...
Retta, Saverio Francesco, Pinton, Paolo, Marchi, Saverio   +2 more
core   +1 more source

Clinical Reasoning: Cerebral cavernous malformations [PDF]

Neurology, 2009
A 40-year-old man presented for management of seizures. His first seizure was 5 years earlier. Evaluation at that time revealed a hemorrhagic lesion near the occipital horn of the left lateral ventricle. Incomplete surgical excision was performed with indeterminate pathology suggestive of an astrocytoma.
Lama M, Chahine, Michel J, Berg
openaire   +2 more sources

Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study

Efficacy and Mechanism Evaluation
Background Symptomatic cerebral cavernous malformations are a rare sporadic or familial disease, which may cause haemorrhagic strokes or epileptic seizures.
Rustam Al-Shahi Salman, Kasia Adamczuk, Richard A Parker, Christopher J Weir, Roberto Latini, Helen Kim, David White, Helen Evans, Jana Bergholtz, Cornelia Lee, Carlos Casaus   +10 more
doaj   +1 more source