Results 61 to 70 of about 634,872 (202)

CCM3 and cerebral cavernous malformation disease [PDF]

Stroke and Vascular Neurology, 2019
Cerebral cavernous malformations (CCMs) are vascular lesions characterised by enlarged and irregular structure of small blood vessels in the brain, which can result in increased risk of stroke, focal neurological defects and seizures. Three different genes, CCM1/Krev/Rap1 Interacting Trapped 1, CCM2/MGC4607 and CCM3/PDCD10, are associated with the CCMs’
Kang Wang, Huanjiao Jenny Zhou, Min Wang
openaire   +2 more sources

Cerebral cavernous malformations: Review of the genetic and protein-protein interactions resulting in disease pathogenesis

Frontiers in Surgery, 2016
Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions comprised of aberrantly enlarged cavernous endothelial channels that can result in cerebral ...
Jacob F. Baranoski, M. Yashar S. Kalani, Joseph M. Zabramski   +2 more
doaj   +1 more source

Postzygotic mosaicism in cerebral cavernous malformation [PDF]

Journal of Medical Genetics, 2019
Background Cerebral cavernous malformations (CCMs) can cause severe neurological morbidity but our understanding of the mechanisms that drive CCM formation and growth is still incomplete. Recent experimental data suggest that dysfunctional CCM3-deficient endothelial cell clones form cavernous lesions in ...
Rath, M., Pagenstecher, Axel, Hoischen, A., Hoischen, A., Felbor, U.   +4 more
openaire   +3 more sources

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, Volume 36, Issue 6, November 2026.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

Cavernous Malformations and Capillary Telangiectasia: A Spectrum within a Single Pathological Entity

, 1991
Cerebral vascular malformations have traditionally been divided into four categories: arteriovenous, venous, cavernous, and capillary telangiectases. A controversy exists about separating the latter two lesions into separate entities.
Peter C. Johnson, Daniele Rigamonti, Burton P. Drayer, Mark N. Hadley, Robert F. Spetzler   +4 more
core   +1 more source

Molecular genetic analysis of cerebral cavernous malformations: An update [PDF]

, 2021
Cerebral cavernous malformations (CCM) can occur either as sporadic or familial form with autosomal dominant inheritance. Three CCM genes have been identified: CCM1 (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10).
Riolo G., Battistini S., Ricci C., Giulia Riolo, Claudia Ricci, Stefania Battistini   +5 more
core   +1 more source

Combination of multiple cerebral cavernous malformations with a falx meningioma: A clinical case

Кубанский научный медицинский вестник
Introduction. Cerebral cavernous malformations may coexist with various disorders of the central nervous system, including brain tumors. There are few descriptions of combined cavernous malformations and meningiomas in the literature.
L. V. Shagal, A. R. Eremyan, A. I. Berdnik, G. R. Obivalina, G. G. Muzlaev   +4 more
doaj   +1 more source

Peculiarities of the cavernous cerebral malformations diagnostic and treatment

Ukrainian Neurosurgical Journal, 2006
On the basis of analysis of 49 cerebral malformations observations are analyzed and the peculiarities of their diagnostic and treatment were distinguished.
O. A. Tsimeyko, A. I. Goncharov, M. Yu. Orlov, I. I. Skorokhoda, O. G. Chernenko   +4 more
doaj   +1 more source

Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease

AGING MEDICINE, Volume 9, Issue 5, Page 464-471, October 2026.
Among 132 older adults, 13 had peripheral artery disease (PAD), identified using the ankle–brachial index. Over approximately 13 months, PAD was associated with increasing middle cerebral artery mean flow velocity, with a significant difference in left‐sided velocity change between groups.
SangMi Noh, Hae‐Eun Shin, YongSoo Shim
wiley   +1 more source

Vascular Permeability in Cerebral Cavernous Malformations [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo.
Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik B W, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A   +13 more
openaire   +3 more sources