Results 61 to 70 of about 6,942 (204)

Postzygotic mosaicism in cerebral cavernous malformation [PDF]

Journal of Medical Genetics, 2019
Background Cerebral cavernous malformations (CCMs) can cause severe neurological morbidity but our understanding of the mechanisms that drive CCM formation and growth is still incomplete. Recent experimental data suggest that dysfunctional CCM3-deficient endothelial cell clones form cavernous lesions in conjunction ...
Rath, M., Pagenstecher, Axel, Hoischen, A., Hoischen, A., Felbor, U.   +4 more
openaire   +3 more sources

Neurovascular Disorders in Pregnancy: Prevalence, Clinical Assessment and Management—A Review of the Literature

The Obstetrician &Gynaecologist, EarlyView.
ABSTRACT Key Content Neurovascular conditions in pregnancy are rare but are associated with poor maternal and fetal outcomes. This review covers the prevalence, clinical presentation, diagnosis and management of neurovascular disorders in pregnancy. The approach to clinical assessment and investigation of pregnant women with acute or changing chronic ...
Amy Newnham, Joshua Odendaal, Toby Keown, Wen‐Xern Chong, Krunal Patel, Vandana Dhingra   +5 more
wiley   +1 more source

Review of familial cerebral cavernous malformations and report of seven additional families

, 2016
Cerebral cavernous malformations are vascular anomalies of the central nervous system characterized by clusters of enlarged, leaky capillaries. They are caused by loss-of-function mutations in KRIT1, CCM2, or PDCD10.
van Steensel, Maurice A. M., de Vos, Ivo J. H. M., Vreeburg, Maaike, Koek, Ger H.   +3 more
core   +1 more source

Limited Impact of Serial Follow-Up Imaging in Clinically Stable Patients With Brainstem Cavernous Malformations

Frontiers in Neurology, 2020
Background: Clinical management of patients with brainstem cavernous malformations (BSCM) is often challenging due to the unpredictable clinical course and lack of high-quality evidence.
Julia Velz, Julia Velz, Flavio Vasella, Flavio Vasella, Yang Yang, Yang Yang, Marian Christoph Neidert, Marian Christoph Neidert, Luca Regli, Luca Regli, Oliver Bozinov, Oliver Bozinov   +11 more
doaj   +1 more source

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Iatrogenic transmission of amyloid beta can cause cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), but the relationship between these phenotypes is unclear. METHODS We retrospectively analyzed standardized neuropsychological and neuroimaging data from 11 patients with iatrogenic CAA (iCAA).
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Edgar Chan, Simon Fandler‐Höfler, Rupert Oliver, Victoria Harvey, Zane Jaunmuktane, John Collinge, David J Werring   +9 more
wiley   +1 more source

Are Cavernous Sinus Hemangiomas and Cavernous Malformations Different Entities?

, 2006
Cavernous hemangiomas that occur within the cavernous sinus (CS) are different from cerebral cavernous malformations (CMs) clinically, on imaging studies, and in their response to treatment.
Jennifer Eschbacher, Gonzalez, L. Fernando, Coons, Stephen, Lekovic, Gregory P., Eschbacher, Jennifer, Gregory P. Lekovic, Porter, Randall W., Spetzler, Robert F., Stephen Coons, L. Fernando Gonzalez, Randall W. Porter, Robert F. Spetzler   +11 more
core   +2 more sources

Stroke‐Mimic: An Intracranial Dural Arteriovenous Fistula Revealed by New‐Onset Seizures and Post‐Ictal Deficit

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Intracranial dural arteriovenous fistulas (iDAVFs) are rare vascular malformations with diverse neurological symptoms depending on their venous drainage pattern. We describe a 59‐year‐old man who presented with transient right‐sided weakness and facial droop following new‐onset seizures. CT demonstrated asymmetric arterial‐phase enhancement of
Michael Van Haute, Mary Martin, Mark Harmon   +2 more
wiley   +1 more source

Vascular Permeability in Cerebral Cavernous Malformations [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo.
Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik B W, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A   +13 more
openaire   +3 more sources

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation [PDF]

, 2022
Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation.
Akagawa, Hiroyuki, Sasaki, Tatsuya, Hiroyuki Akagawa, Nakano, Yumiko, Taijun Yunoki, Koji Abe, Yamashita, Toru, Omote, Yoshio, Mami Takemoto, Yumiko Nakano, Nozomi Hishikawa, Emi Nomura, Nomura, Emi, Yunoki, Taijun, Tatsuya Sasaki, Morihara, Ryuta, Toru Yamashita, Takemoto, Mami, Ryuta Morihara, Yoshio Omote, Hishikawa, Nozomi, Abe, Koji   +21 more
core   +1 more source