Results 51 to 60 of about 9,788 (221)

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Cell Proliferation, EarlyView.
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song, Hyejin Jo, Seokchan Jeong, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Two cases of ventral midbrain cavernous malformations successfully removed through orbitozygomatic interpeduncular approach

Interdisciplinary Neurosurgery, 2016
Ventral midbrain cavernous malformations are rare, and annual bleeding rate is higher than supratentorial lesions. Rebleeding rate is also high if surgical resection is incomplete. The ventral midbrain is deeply located and surrounded by many perforators,
Keiichi Tsuji, Naoki Nitta, Kenji Takagi, Toshihiro Yokoi, Kazuhiko Nozaki   +4 more
doaj   +1 more source

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation

Brain and Behavior, Volume 16, Issue 2, February 2026.
Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Xuesai Zhu, Yizhi Yao, Tengbo Yu, Xiao Xiao   +3 more
wiley   +1 more source

Molecular diagnosis in cerebral cavernous malformations

Neurología (English Edition), 2017
Introduction: Cerebral cavernous malformations (CCMs; OMIM 116860) are enlarged vascular cavities without intervening brain parenchyma whose estimated prevalence in the general population is between 0.1% and 0.5%.
R. Mondejar, M. Lucas
doaj   +1 more source

Familiäre Kavernome des Zentralnervensystems: Eine klinische und genetische Studie an 15 deutsche Familien [PDF]

, 2018
Zusammenfassung: 1928 beschrieb Hugo Friedrich Kufs erstmalig eine Familie mit zerebralen, retinalen und kutanen Kavernomen. Mittlerweile wurden über 300 weitere Familien beschrieben.
Andermann, E., Andermann, F., Baumann, C., Bertalanffy, H., Dichgans, J., Elger, C., Hopf, H., Hopf, N., Keidel, M., Kleider, A., Nowak, G., Pfeiffer, R., Rouleau, G., Schramm, J., Siegel, A., Spuck, S., Stefan, H., Sure, U., Verlaan, D.   +18 more
core  

Extensive Intracerebral Hemorrhage Involving Basal Ganglia and Frontal Lobe With Intraventricular and Subarachnoid Extension in a Triplet Pregnancy Following In Vitro Fertilization: A Case Report and Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Triplet births, particularly those achieved by assisted reproductive technologies, entail markedly elevated maternal and fetal risks, including hypertensive diseases. Intracerebral hemorrhage is an uncommon but devastating complication during the postpartum period.
Raman Goit, Prakash Gupta, Linh Nguyen, Shachi Patel, Karan Kumar Rana, Suman Jaiswal, Prateeti Bekoju, Ranju Shrestha, Daniel Nguyen   +8 more
wiley   +1 more source

Multiple intracranial cavernous angiomas: A rare case series

Journal of the Scientific Society, 2012
Cavernous angiomas are cerebral cavernous malformations and they are relatively rare lesions. Two forms of cavernous angiomas have been described: a sporadic form, in which patients usually have a single lesion, and a familial form, the hallmarks of ...
Pradeepgoud H Patil, A C Shetti, Ashwin S Patil, Vinaykumar C Udasi, Kiran S Desai, Tejas B Gosalia   +5 more
doaj   +1 more source

Atlas of Nervous System Vascular Malformations: A Systematic Review

Life, 2022
Vascular malformations are frequent in the head and neck region, affecting the nervous system. The wide range of therapeutic approaches demand the correct anatomical, morphological, and functional characterization of these lesions supported by imaging ...
Carlos Castillo-Rangel, Gerardo Marín, Karla Aketzalli Hernandez-Contreras, Cristofer Zarate-Calderon, Micheel Merari Vichi-Ramirez, Wilmar Cortez-Saldias, Marco Antonio Rodriguez-Florido, Ámbar Elizabeth Riley-Moguel, Omar Pichardo, Osvaldo Torres-Pineda, Helena G. Vega-Quesada, Ramiro Lopez-Elizalde, Jaime Ordoñez-Granja, Hugo Helec Alvarado-Martinez, Luis Andrés Vega-Quesada, Gonzalo Emiliano Aranda-Abreu   +15 more
doaj   +1 more source

Limited Impact of Serial Follow-Up Imaging in Clinically Stable Patients With Brainstem Cavernous Malformations

Frontiers in Neurology, 2020
Background: Clinical management of patients with brainstem cavernous malformations (BSCM) is often challenging due to the unpredictable clinical course and lack of high-quality evidence.
Julia Velz, Julia Velz, Flavio Vasella, Flavio Vasella, Yang Yang, Yang Yang, Marian Christoph Neidert, Marian Christoph Neidert, Luca Regli, Luca Regli, Oliver Bozinov, Oliver Bozinov   +11 more
doaj   +1 more source

PDCD10 gene mutations in multiple cerebral cavernous malformations. [PDF]

PLoS ONE, 2014
Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits.
Maria Sole Cigoli, Francesca Avemaria, Stefano De Benedetti, Giovanni P Gesu, Lucio Giordano Accorsi, Stefano Parmigiani, Maria Franca Corona, Valeria Capra, Andrea Mosca, Simona Giovannini, Francesca Notturno, Fausta Ciccocioppo, Lilia Volpi, Margherita Estienne, Giuseppe De Michele, Antonella Antenora, Leda Bilo, Antonietta Tavoni, Nelia Zamponi, Enrico Alfei, Giovanni Baranello, Daria Riva, Silvana Penco   +22 more
doaj   +1 more source