Results 141 to 150 of about 609,733 (342)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Additional file 5: of Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex

, 2018
Matthew Schwede, Shailender Nagpal, Michael J. Gandal, Neelroop Parikshak, Károly Mirnics, Daniel H. Geschwind, Eric M. Morrow   +6 more
openalex   +1 more source

Spermine Dependent Activation of the N-Methyl-D-Aspartate (NMDA) Receptor in the Cerebral Cortex of Newborn Piglets. † 1771 [PDF]

, 1997
Alan B. Zubrow, Yoshihiro Numagami, Jane E. McGowan, Eric Lombardini, Om P. Mishra, Maria Delivoria‐Papadopoulos   +5 more
openalex   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Astrocyte End-Feet in Germinal Matrix, Cerebral Cortex, and White Matter in Developing Infants [PDF]

, 2006
Nadine El-Khoury, Alex Braun, Furong Hu, Maya Pandey, Maiken Nedergaard, Edmund F. LaGamma, Praveen Ballabh   +6 more
openalex   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

The Distribution of MAP-2 Phosphorylation in Cerebral Cortex of Long-Tailed Monkey Fetuses (Macaca fascicularis) in the Last Trimester of Gestation

Indonesian Journal of Biotechnology, 2015
Memories are storage in cholinoceptive cells, the cells which are enriched with microtubule-associated protein 2 (MAP-2) that localized in the neuronal dendrite and the cell bodies.
Tri Wahyu Pangestiningsih, Vidya Irawan, Erni Sulistiawati   +2 more
doaj  

Quantitative Proteomics Identifies Surfactant-Resistant α-Synuclein in Cerebral Cortex of Parkinsonism-Dementia Complex of Guam but Not Alzheimer's Disease or Progressive Supranuclear Palsy [PDF]

, 2007
Wan Yang, Randall L. Woltjer, Izabela Sokal, Catherine Pan, Yan Wang, Mary Brodey, Elaine R. Peskind, James B. Leverenz, Jing Zhang, Daniel P. Perl, Douglas Galasko, Thomas J. Montine   +11 more
openalex   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source