Results 161 to 170 of about 129,062 (275)

Angiogenic Biomarkers and Neonatal Outcomes in Suspected Preeclampsia: Retrospective Cohort Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Placental growth factor (PlGF) and soluble fms‐like tyrosine kinase 1 (sFlt1) are two biomarkers associated with placental function and the sFlt‐1/PlGF ratio is frequently used for risk assessment and prediction of preeclampsia in pregnancy. Objective To assess the association between elevated sFlt‐1/PlGF ratio and adverse neonatal outcomes in
Genevieve P. G. Fung   +7 more
wiley   +1 more source

Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)

open access: yesIntegrative Zoology, EarlyView.
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao   +6 more
wiley   +1 more source

Rare but relevant: MDMA and hyponatraemia

open access: yesAddiction, EarlyView.
Abstract Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonly used psychoactive drugs, specifically among young adults and in nightlife and recreational party contexts.
Maria Rita Garcia   +2 more
wiley   +1 more source

Personalized Cancer Vaccines in the Clinical Trial Pipeline

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
This study analyzes the current landscape of personalized cancer vaccine clinical trials, highlighting trends in vaccine platforms, trial phases, and geographic distribution. Peptide and dendritic cell vaccines dominate early‐stage research, with promising immune responses observed in melanoma, glioblastoma, and urothelial cancer trials.
Liudmila Iamukova, Elena Alferova
wiley   +1 more source

Outcomes in Patients Requiring VENO‐Venous Extracorporeal Membrane Oxygenation After Cardiac Surgery: An Analysis From the PELS‐1 Study

open access: yesArtificial Organs, EarlyView.
We report an insight from the PELS‐1– a multicentre, international registry focusing on postocardiotomy extracorporeal support use between 2000 and 2020. We focused on 24/2163 (1.1%) patients requiring V‐V ECMO after cardiac surgery. Mortality was high, with 21.7% of patients discharged alive and an overall 1‐year survival probability of 12.5 ...
Pasquale Nardelli   +39 more
wiley   +1 more source

Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage. [PDF]

open access: yesJ Cereb Blood Flow Metab
Yang BSK   +11 more
europepmc   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen   +3 more
wiley   +1 more source

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