Results 171 to 180 of about 648,897 (295)

Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke. [PDF]

Nat Commun
Guo S, Li AQ, Chen FK, Weng DZ, Wang Z, Yang C, Zhang YJ, Zhang Y, Chang X, Liang HB, Liu J.   +10 more
europepmc   +1 more source

A Rapid T1‐Independent Sequence for Cerebrospinal Fluid Water Standard Correction: Application to Improved Proton Density Mapping in Brain

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve brain water content measures relative to cerebrospinal fluid (CSF) by including a rapid T1‐independent sequence to correct for CSF T1 errors. Methods Proton density (PD) was estimated from a 3D multiple echo gradient echo sequence by extrapolating to TE = 0 and then correcting for T1 losses using a T1 map from 3D MP2RAGE. To
Kiarash Jalali, Nashwan Naji, Peter Seres, Alan H. Wilman   +3 more
wiley   +1 more source

Development and validation of a prediction model for postoperative cerebral edema progression in emergency traumatic brain injury patients. [PDF]

Medicine (Baltimore)
Zhang F, Zheng J, Liu Y, Lin H.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Efficacy of nimodipine plus mannitol in the treatment of cerebral edema after intracerebral hemorrhage and its impact on cerebral hemodynamic parameters. [PDF]

Am J Transl Res
Huang L, Yang Q, Tang Y.
europepmc   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Incidence, predictors, and outcomes of malignant cerebral edema after acute basilar artery occlusion thrombectomy. [PDF]

J Neurointerv Surg
Xu X, Nguyen TN, Qiu Z, Xu Y, Huang Z, Li W, Sun W, Guo Y, Xu J, Jiang S, Hu H, Xie F, Yang G, Xu H, Xu G, Huang X.   +15 more
europepmc   +1 more source

Noninvasive or minimally invasive neuromodulation in animal models of acute ischemic stroke: A systematic review and meta‐analysis

Neuroprotection, EarlyView.
This systematic review and meta‐analysis assessed the cytoprotective effects of neuromodulation in preclinical models of ischemic stroke. Pooled analyses showed that neuromodulation significantly reduced infarct volume and improved neurological outcomes.
Igor Caitano Salles, Mateus Paquesse Pellegrino, Jessica Borges Kroth, Clara Lucato dos Santos, Luca Schiliro Tristao, Jullyanna Sabrysna Morais Shinosaki, Wanderley Marques Bernardo, Adriana Bastos Conforto   +7 more
wiley   +1 more source

Malignant cerebral edema after endovascular thrombectomy: a multimodal prediction model based on post-thrombectomy cerebral hyperdensity and natural language processing. [PDF]

Front Med (Lausanne)
Song G, Fu J, Chen Y, Shen Y, Hong J, Liu F, Gai S, Liu H, Tong D, Cheng S, Han J, Fu J, Ding J.   +12 more
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source