Results 91 to 100 of about 1,234,400 (280)

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. [PDF]

open access: yes, 2016
Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications ...
Adibhatla   +133 more
core   +3 more sources

Matrix Metalloproteinases in Cerebral Ischemia [PDF]

open access: yesJournal of Clinical Neurology, 2006
Matrix metalloproteinases (MMPs) are involved in the pathophysiology of several central nervous system diseases that share common pathogeneses, such as disruption of the blood-brain barrier (BBB), neuroinflammation, oxidative stress, and remodeling of the extracellular matrix (ECM). In early ischemic injury, MMPs participate in disruption of the BBB by
Seol-Heui Han, Hahn Young Kim
openaire   +3 more sources

DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury

open access: yesNeural Regeneration Research, 2023
Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and ...
Guang Shi   +3 more
doaj   +1 more source

Analytic and Numerical Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids [PDF]

open access: yes, 2015
Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically applicable, it will be essential to understand internal dynamics and signaling molecule concentrations throughout the ...
arxiv   +1 more source

Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]

open access: yes, 2017
Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core  

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

open access: yes, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento   +91 more
core   +1 more source

TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice

open access: yesJournal of Cerebral Blood Flow and Metabolism, 2015
Toll-like receptor 4 (TLR4) contributes to cerebral ischemia/reperfusion (I/R) injury and is a potential target for the treatment of ischemic stroke.
F. Hua   +6 more
semanticscholar   +1 more source

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

open access: yes, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard   +2 more
core   +1 more source

Inhibition of the cGAS–STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury

open access: yesNeural Regeneration Research
The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart, liver, brain, and kidney, but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.
Hang Yang   +6 more
doaj   +1 more source

Cyclooxygenase inhibition in ischemic brain injury [PDF]

open access: yesCurrent Pharmaceutical Design 2008; 14(14):1401-1418, 2008
Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is known to be actively involved in the neuroinflammatory events leading to neuronal death after ischemia.
arxiv  

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