Results 111 to 120 of about 253,504 (317)

Viscosity Effects on Blood Flow Dynamics: Influence of Isovolemic Hemodilution on Focal Cerebral Ischemia

In recent years there has been considerable clinical interest in the efficacy of both hypervolemic hemodilution [6, 7, 20] and isovolemic hemodilution [9, 26] in the prevention or treatment of cerebral ischemia.
Karacostas, D., Hyodo, A., Zervas, N. T., Tu, Y.-K., Candia, G., Heros, R. C., LeGree, K.   +6 more
core   +1 more source

Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice

, 2011
Background: FTY720, an immunomodulator derived from a fungal metabolite which reduces circulating lymphocyte counts by increasing the homing of lymphocytes to the lymph nodes has recently gained interest in stroke research.
Czech-Zechmeister, Bozena, Pfeilschifter, Josef (Prof. Dr.), Bożena Czech-Zechmeister, Marian Sujak, Thomas A Wichelhaus, Sujak, Marian, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Wichelhaus, Thomas Alexander, Förch, Christian, Waltraud Pfeilschifter   +11 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Cerebral microdialysis: research technique or clinical tool

, 2006
Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a bedside monitor to provide on-line analysis of brain tissue biochemistry during neuro-intensive care.
Tisdall, M.M., Smith, M.
core  

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Estimation of thiocetam influence on glutathione link of thiol disulfide cerebral system in conditions of experimental chronic ischemia

Patologìâ, 2015
Aim. Pharmacological remodeling of pathologic changes when cerebral ischemia takes place is actual task for today. With the purpose of thiocetam neuroprotective properties studying in conditions of experimental chronic cerebral ischemia the ...
A. V. Demchenko, І. F. Belenichev
doaj   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Arachidonic Acid and Cerebral Ischemia Risk: A Systematic Review of Observational Studies

Cerebrovascular Diseases Extra, 2014
Background: Arachidonic acid (ARA) is a precursor of various lipid mediators. ARA metabolites such as thromboxane A2 cause platelet aggregation and vasoconstriction, thus may lead to atherosclerotic disease.
Mai Sakai, Saki Kakutani, Hisanori Tokuda, Toshihide Suzuki, Masaru Kominami, Kahori Egawa, Kayo Saito, Tomohiro Rogi, Hiroshi Kawashima, Hiroshi Shibata, Satoshi Sasaki   +10 more
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source