Results 121 to 130 of about 253,504 (317)

Mechanics and composition of middle cerebral arteries from simulated microgravity rats with and without 1-h/d -Gx gravitation [PDF]

, 2014
Background: To elucidate further from the biomechanical aspect whether microgravity-induced cerebral vascular maladaptation might be a contributing factor to postflight orthostatic intolerance and the underlying mechanism accounting for the potential ...
Zhang, Li-Fan, Gao, Fang, Cheng, Jiu-Hua, Li-Fan Zhang, Yun-Gang Bai, Bai, Yun-Gang, Boscolo, Marco, Zhang, Xiang, Marco Boscolo, Fang Gao, Xiao-Feng Huang, Huang, Xiao-Feng, Jiu-Hua Cheng, Xiang Zhang   +13 more
core   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Influence of Orphanin FQ Intracerebroventricular Administration on Electroacupuncture's Anti-cerebral Ischemic Effect in Rats

针刺研究, 2002
Objective: To verify the effect of Orphanin (O) FQ on cerebral ischemia and observe its influence on electroacupuncture(EA)'s anti cerebral ischemia.
高焕民, 程介士
doaj  

Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

Frontiers in Pharmacology
Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization of blood vessels to facilitate timely reperfusion is the primary clinical approach; however, reperfusion itself may trigger cerebral ischemia-reperfusion ...
Kailin Yang, Kailin Yang, Liuting Zeng, Qi He, Shanshan Wang, Hao Xu, Jinwen Ge, Jinwen Ge   +7 more
doaj   +1 more source

El Papel de las metaloproteinasas de matriz en la fase aguda del ictus isquémico

, 2004
El ictus cardioembólico o embolia cerebral de origen cardíaco es la oclusión de una arteria cerebral por un émbolo procedente del corazón. Con frecuencia origina infartos cerebrales de tamaño importante, presenta elevadas tasas de recanalización ...
Montaner Villalonga, Joan, Montaner, Joan   +1 more
core  

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia

, 2002
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Candelario-Jalil, Eduardo, Giuliani, Attilia, A. Giuliani, Merino, Nelson, Gonzalez-Falcon, Armando, Martinez-Sanchez, Gregorio, M. Garcia Cabrera, N. Merino, E. Candelario Jalil, Leon, Olga S., A. Gonzalez Falcon, O. S. Leon, D. Alvarez, Garcia-Cabrera, Michel, G. Martinez Sanchez, Alvarez, Dalia   +15 more
core   +1 more source