Results 131 to 140 of about 253,504 (317)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

Experimental Cerebral Infarction in the Dog : Cerebral Ischemia and Revascularization

open access: yes, 1985
Experimental cerebral infarction was produced in dogs by injecting one or two silicone rubber cylinders through the cervical internal carotid artery (permanent group).
柴田, 尚武   +3 more
core  

Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats [PDF]

open access: yes, 2012
There is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper.
Liu, Zhenquan   +5 more
core  

Synthetic MRI Neuroimaging Correlates of Frailty: Correlations Between Frailty Scales and Brain Structural Integrity

open access: yesAGING MEDICINE, EarlyView.
Frailty was associated with decreased gray and white matter brain volumes in older adults. Synthetic MRI further revealed relaxometry alterations correlated with frailty severity across multiple clinical scales. ABSTRACT Objectives Frailty, a common condition in the elderly, is characterized by a decline in physiological reserves and an increased ...
Yuhui Chen   +7 more
wiley   +1 more source

Research Advances in Mongolian Gerbil Models of Cerebral Ischemia and Auditory Impairment

open access: yesShiyan dongwu yu bijiao yixue
The Mongolian gerbil currently used as laboratory animals worldwide all originates from China. As early as the 1930s, wild Mongolian gerbils were domesticated and introduced into medical research.
ZHANG Zishan   +3 more
doaj   +1 more source

The Impact of Early Postoperative Blood Pressure Variability and Hypertension Status on 90‐Day Functional Outcomes in Acute Ischemic Stroke due to Large Vessel Occlusion Patients Treated With Mechanical Thrombectomy

open access: yesAGING MEDICINE, EarlyView.
Early postoperative blood pressure variability independently predicts poor 90‐day functional outcomes in AIS‐LVO patients after mechanical thrombectomy, with the adverse effect amplified in those with pre‐existing hypertension. Maintaining stable blood pressure in the early postoperative period may improve recovery in this high‐risk population ABSTRACT
Yunpeng Liu   +4 more
wiley   +1 more source

How long is too long for cerebral cooling after ischemia in fetal sheep?

open access: yes, 2015
Therapeutic hypothermia can partially reduce long-term death and disability in neonates after hypoxic-ischemic encephalopathy. The aim of this study was to determine whether prolonging the duration of cooling from 3 days to 5 days could further improve ...
Wassink, Guido   +5 more
core   +1 more source

A Steerable and Expandable Magnetic Aspiration Catheter for Enhanced Aspiration Thrombectomy

open access: yesAdvanced Intelligent Systems, EarlyView.
This article presents a novel magnetic aspiration catheter (MAC) that can be both actively steered and undergo distal‐end expansion via externally applied magnetic fields. The MAC facilitates precise branch selection and enhances clot engagement by improving endovascular navigation and aspiration efficiency. Phantom experiments validate its feasibility
Hakjoon Lee   +7 more
wiley   +1 more source

Effects of Exercise Preconditioning on Neurotrophin-4 and Tropomyosin Receptor Kinase B Expression in the Hippocampal CA1 Region Following Transient Global Cerebral Ischemia/Reperfusion in Wistar Rats

open access: yesMedical Laboratory Journal, 2019
Background and Objectives: Cerebral ischemia causes irreversible structural and functional damage in certain areas of the brain, especially in the hippocampus.
Mohtaram Yazdanian   +3 more
doaj  

Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma

open access: yesAdvanced Intelligent Systems, EarlyView.
A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach   +5 more
wiley   +1 more source

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