Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra [PDF]
, 2008 We describe a novel magnetic resonance imaging technique for detecting metabolism indirectly through changes in oxyhemoglobin:deoxyhemoglobin ratios and T2* signal change during ‘oxygen challenge’ (OC, 5 mins 100% O2). During OC, T2* increase reflects O2
Barrie Condon +14 more
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Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
A review of medicinal herbs with antioxidant properties in the treatment of cerebral ischemia and reperfusion [PDF]
, 2015 BACKGROUND AND OBJECTIVE: Stroke is the second most common cause of death and a major cause of disability in individuals aged over 65 years, worldwide.
Bigdeli, M.R. +2 more
core
Advanced Science, EarlyView.Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley +1 more source
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
Advanced Science, EarlyView.The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu +22 more
wiley +1 more source
Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat [PDF]
Background and the Purpose of the study: Central Angiotensin Converting Enzyme (ACE) has an important role on cerebral microcirculation and metabolism.
دهقان, غلامعباس +1 more
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Attenuation of Focal Cerebral Ischemic Injury Following Post Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat [PDF]
Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from ...
دهقان, غلامعباس +1 more
core +1 more source
Advanced Science, EarlyView.This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein +9 more
wiley +1 more source
Advanced Science, EarlyView.The study has developed the first clinically validated hybrid EEG‐fNIRS brain‐computer interface fusion framework that systematically overcomes cross‐subject generalization barriers through a novel Wasserstein metric‐driven neural template selection mechanism.
Danyang Chen +18 more
wiley +1 more source
Corrigendum: Cerebral ischemia and neuroregeneration
Neural Regeneration Research, 2022 [This corrects the article DOI: 10.4103/1673-5374.228711].
openaire +3 more sources