Results 61 to 70 of about 161,579 (302)

DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury

Neural Regeneration Research, 2023
Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and ...
Guang Shi, Juan Feng, Ling-Yan Jian, Xin-Yu Fan   +3 more
doaj   +1 more source

Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery [PDF]

, 2019
Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status.
Kühn, Eike C., Kühn-Heid, Ellen C. D., Minich, Waldemar B., Ney, Julia, Schomburg, Lutz, Schwiebert, Christian, Seelig, Julian, Stoppe, Christian, Wendt, Sebastian   +8 more
core   +1 more source

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source

NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis

Genes and Diseases, 2019
Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide. NDRG4 has been shown to protect against cerebral ischemia, although the underlying mechanisms remain largely unclear.
Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing Li   +6 more
doaj   +1 more source

Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Journal of Neuroinflammation, 2023
Background and purpose Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv   +7 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review [PDF]

, 2009
Background Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke.
Alvarez-Dolado, Bath, Bath, Claire L. Gibson, Crain, Crossley, del Zoppo, Egger, England, Fisher, Gibson, Gibson, Gibson, Han, Hasselblatt, Hermann, Jendelova, Kawada, Kollmar, Komine-Kobayashi, Lan, Lee, Lees, Macleod, Matchett, Minnerup, Nagata, Philip M.W. Bath, Schabitz, Schneider, Schneider, Sehara, Sehara, Sena, Sevimli, Shuaib, Shyu, Shyu, Shyu, Six, Solaroglu, Solaroglu, Sprigg, Sprigg, Sykova, Taguchi, Timothy J. England, Toth, Vellenga, Wardlaw, Willmot, Yanqing, Zhao, Zhao, Zsebo, Zucali   +55 more
core   +2 more sources

Comprehensive analysis of lncRNA expression profiles in rats with cerebral ischemia-reperfusion injury after treatment with 20(R)-ginsenoside Rg3 [PDF]

, 2022
Yuan Yang, Bo He, Renhua Yang, Deyun Chen, Xiaochao Zhang, Fajing Li, Zhiqiang Shen, Peng Chen   +7 more
openalex   +1 more source