Results 131 to 140 of about 1,618,966 (304)

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Modulation of cerebral ketone metabolism following traumatic brain injury in humans.

, 2018
Adaptive metabolic response to injury includes the utilization of alternative energy substrates - such as ketone bodies (KB) - to protect the brain against further damage.
Miroz, J.P., Carteron, L., Foltzer, F., Masoodi, M., Bernini, A., Oddo, M., Beaumont, M., Hartweg, M., Abed-Maillard, S., Eckert, P., Christinat, N., Morelli, P., Solari, D., Cuenoud, B., Masoodi, Mojgan, Abed-Maillard S, Foltzer, Fabien, Cuenoud, Bernard, Miroz, John-Paul, Eckert, Philippe, Hartweg M, Solari, Daria, Beaumont, Maurice, Oddo M, Masoodi M, Bernini, Adriano, Carteron, Laurent, Eckert P, Solari D, Miroz JP, Beaumont M, Christinat, Nicolas, Cuenoud B, Carteron L, Christinat N, Foltzer F, Hartweg, Mickael, Oddo, Mauro, Bernini A, Morelli P, Morelli, Paola, Abed-Maillard, Samia   +41 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning. [PDF]

J Med Toxicol, 2023
Alomaja O, Shofer FS, Greenwood JC, Piel S, Clayman C, Mesaros C, Kao SH, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH.   +10 more
europepmc   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets. [PDF]

Front Pediatr, 2023
Andelius TCK, Bøgh N, Pedersen MV, Omann C, Andersen M, Andersen HB, Hjortdal VE, Pedersen M, Rasmussen MB, Kyng KJ, Henriksen TB.   +10 more
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

cFOS expression in the prefrontal cortex correlates with altered cerebral metabolism in developing germ-free mice. [PDF]

Front Mol Neurosci, 2023
Pate T, Anthony DC, Radford-Smith DE.
europepmc   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Differences in Cerebral Metabolism between Moderate- and High-Severity Groups of Patients with Out-of-Hospital Cardiac Arrest Undergoing Target Temperature Management. [PDF]

Brain Sci, 2023
You Y, Kang C, Jeong W, Ahn HJ, Park JS, Min JH, In YN, Lee JK, Jeon SY.   +8 more
europepmc   +1 more source