Results 41 to 50 of about 435,514 (353)

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

Frontiers in Aging Neuroscience, 2022
The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image ...
Jie Tang, Miaoyi Zhang, Na Liu, Yang Xue, Xue Ren, Qi Huang, Langfeng Shi, Jianhui Fu   +7 more
semanticscholar   +1 more source

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

JAMA Neurology, 2022
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology.
H. Markus, W. M. van der Flier, E. Smith, P. Bath, G. Biessels, E. Briceño, Amy Brodtman, H. Chabriat, Christopher P L H Chen, F. de Leeuw, M. Egle, A. Ganesh, Marios K. Georgakis, R. Gottesman, S. Kwon, L. Launer, Vincent C. T. Mok, J. O'Brien, Lois Ottenhoff, S. Pendlebury, E. Richard, P. Sachdev, R. Schmidt, Melanie Springer, Stefan Tiedt, J. Wardlaw, A. Verdelho, A. Webb, D. Werring, M. Duering, D. Levine, M. Dichgans   +31 more
semanticscholar   +1 more source

HTRA1-related autosomal dominant cerebral small vessel disease

Chinese Medical Journal, 2021
. Background. Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL ...
Jing-Yi Liu, Yi-Cheng Zhu, Li-Xin Zhou, Yan-Ping Wei, Chen-Hui Mao, Li-Ying Cui, Bin Peng, Ming Yao, Xin Chen   +8 more
doaj   +1 more source

Inflammatory biomarkers and cerebral small vessel disease: a community-based cohort study

Stroke and vascular neurology, 2022
Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according to disease status and study designs. The present study
Dingding Zhang, Yuan Cao, Jingwei Mu, Yiming Liu, F. Gao, F. Han, F. Zhai, Li-xin Zhou, J. Ni, M. Yao, Ming-Li Li, Z. Jin, Shu-yang Zhang, L. Cui, Yong Shen, Yicheng Zhu   +15 more
semanticscholar   +1 more source

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

International Journal of Stroke, 2022
Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries.
B. Lam, Yuan Cai, R. Akinyemi, G. Biessels, H. van den Brink, Christopher L H Chen, Chin Wai Cheung, King Ngai Chow, Henry Kh Chung, M. Duering, Siu Ting Fu, Deb Gustafson, S. Hilal, Vincent Ming Ho Hui, R. Kalaria, Sangyun Kim, M. Lam, F. de Leeuw, A. Li, H. Markus, A. Marseglia, Huijing Zheng, J. O'Brien, L. Pantoni, P. Sachdev, E. Smith, J. Wardlaw, Vincent C T Mok   +27 more
semanticscholar   +1 more source

The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease

Biomolecules, 2022
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu-Syuan Tian, Mengxi Zhao, Yiyi Chen, Mo Yang, Yilong Wang   +4 more
semanticscholar   +1 more source

Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis [PDF]

, 2015
Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of studies on the association between stiffness, cerebral small vessel disease and cognitive ...
Henry, Ronald M. A., Launer, Lenore J., Protogerou, Athanase D., Schram, Miranda T., Stehouwer, Coen D. A., van Sloten, Thomas T.   +5 more
core   +1 more source

Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease

Frontiers in Neurology, 2022
Cerebral small vessel disease (CSVD) poses a serious socio-economic burden due to its high prevalence and severe impact on the quality of life of elderly patients.
T. Bai, Shijia Yu, Juan Feng
semanticscholar   +1 more source

Large-vessel correlates of cerebral small-vessel disease [PDF]

Neurology, 2013
Our aim was to investigate the relationship of carotid structure and function with MRI markers of cerebral ischemic small-vessel disease.The study comprised 1,800 participants (aged 72.5 ± 4.1 years, 59.4% women) from the 3C-Dijon Study, a population-based, prospective cohort study, who had undergone quantitative brain MRI and carotid ultrasound.
Pierre Boutouyrie, Mahmoud Zureik, Christophe Tzourio, Christophe Tzourio, Sabrina Schilling, Bernard Mazoyer, Fernando Pico, Yi-Cheng Zhu, Yi-Cheng Zhu, Marion Brisset, Stéphane Laurent, Carole Dufouil, Carole Dufouil, Stéphanie Debette, Stéphanie Debette   +14 more
openaire   +5 more sources