Results 321 to 330 of about 173,118 (376)

OCTA changes of retinal microvessels and thickness in moyamoya disease. [PDF]

Sci Rep
Qian XZ, Chen C, Li HL, Zhong L, Wei H, Ge QM, Hu JY, Hong Q, Wang XY, Zeng YM, Chen X, Wang YX, Pei CG, Shao Y.   +13 more
europepmc   +1 more source

Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein

Brain Pathology, EarlyView.
This study investigated whether brain regions with distinct predominance of α‐synuclein (αSyn) cytopathologies show different αSyn seeding patterns in multiple system atrophy (MSA) and Lewy body disease (LBD), using an interdisciplinary approach. High seeding activity is observed in regions with oligodendrocytic‐predominant αSyn pathology in MSA.
Ain Kim, Ivan Martinez‐Valbuena, Krisztina Danics, Shelley L. Forrest, Gabor G. Kovacs   +4 more
wiley   +1 more source

Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability.
Tamar Woudenberg, M. Leontien van der Bent, Veerle Kremer, Ingeborg S. E. Waas, Mat J. A. P. Daemen, Reinier A. Boon, Paul H. A. Quax, A. Yaël Nossent   +7 more
wiley   +1 more source

Global research trends on the links between glymphatic system and cognition: A bibliometric analysis (2009-2023). [PDF]

Medicine (Baltimore)
Ying X, Xu J, Yu Q, Wang X, Lan S, Hu L, Zhang Y, Han D.   +7 more
europepmc   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Chronic kidney disease as a catalyst for cerebral microbleeds: understanding the underlying mechanisms and treatment approaches. [PDF]

Front Med (Lausanne)
Yang J, Chen X, Cao X, Yang H, Liu P, Yin X, Zhang X, Chen Z.   +7 more
europepmc   +1 more source

Aging and Multiple Sclerosis

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease. While typically diagnosed in young adults, late‐onset MS (LOMS, onset > 50 years) is becoming increasingly recognized, presenting with distinct features such as higher rates of progressive onset and motor symptoms.
Takuya Matsushita
wiley   +1 more source

Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease. [PDF]

Aging Clin Exp Res
Yang S, Jiang J, Wang L, Zhao M, Li W, Duan Y, Ren Q, Jiang T, Jiang S, Zhang H, Wang Y, Chen W, Xu J.   +12 more
europepmc   +1 more source

The flavonoid of <i>Dracocephalum heterophyllum</i> Benth. ameliorates cerebral small vessel disease by inhibiting the autophagy via Angs-Tie2 signaling pathway. [PDF]

Front Pharmacol
Liu L, He W, Liu S, Li Y, Wang P, Yan F, Yang W, Yang Y, Guo J.   +8 more
europepmc   +1 more source

Plasma glial fibrillary acidic protein as a biomarker of blood-brain barrier integrity in patients with occult cerebral small vessel disease. [PDF]

Am J Transl Res
Ma P, Gu G, Liu L, Wang Y, Chen J.
europepmc   +1 more source