Humanin: a novel central regulator of peripheral insulin action. [PDF]
PLoS ONE, 2009 Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD).
Radhika H Muzumdar +12 more
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Achievement of multiple therapeutic targets for cardiovascular disease prevention. Retrospective analysis of real practice in Italy [PDF]
, 2018 Background: Pharmacological therapy in patients at high cardiovascular (CV) risk should be tailored to achieve recommended therapeutic targets. Hypothesis: To evaluate individual global CV risk profile and to estimate the control rates of multiple ...
American Diabetes Association +33 more
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Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]
, 2018 Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent +2 more
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Jurnal Penyakit Dalam Indonesia, 2018 Introduction. Vascular calcification measured by carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (DM) patient is a predictor for cerebro-cardiovascular event.
Shirly Elisa Tedjasaputra +3 more
doaj +1 more source
Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study. [PDF]
, 2018 BackgroundThe p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease.MethodsTo expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males ...
Brand, Eva +15 more
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PLoS ONE, 2012 BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce +11 more
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Zhongguo cuzhong zazhi代谢危险因素是脑血管病的重要影响因素。随着代谢性脑血管病概念的提出，如何通过干预代谢危险因素改善此类患者的预后是未来重要的研究方向。代谢危险因素可相互影响并协同作用，降压、调脂、控制血糖等对传统代谢危险因素的干预可有效降低脑血管病的发病率和复发率；抗炎、补充维生素、调节肠道菌群等对残余代谢危险因素的干预同样是影响脑血管病发病及预后的重要措施。新型代谢药物“一专多能”的特点为代谢性脑血管病的治疗和管理提供了新的思路。本综述总结干预代谢危险因素对脑血管病影响的循证医学证据 ...
张方圆, 薛婧, 许杰, 王拥军 ZHANG Fangyuan, XUE Jing, XU Jie, WANG Yongjun
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Hepatic encephalopathy: a neurochemical, neuroanatomical, and neuropsychological study. [PDF]
, 2006 Hepatic encephalopathy (HE) is normally diagnosed by neuropsychological (NP) tests, which are not very specific and do not reveal the underlying pathology.
Binesh, Nader +11 more
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Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders
Journal of Lipid Research, 1997 Peroxisomal disorders arise either from defects in the biogenesis of peroxisomes or from the defective synthesis of one or more peroxisomal enzymes. These defects result in metabolic disturbances in peroxisomal beta-oxidation of various fatty acids and ...
Y Y van der Hoek +6 more
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Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]
, 2010 Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO +4 more
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