Results 31 to 40 of about 4,975 (118)

Humanin: a novel central regulator of peripheral insulin action. [PDF]

PLoS ONE, 2009
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD).
Radhika H Muzumdar, Derek M Huffman, Gil Atzmon, Christoph Buettner, Laura J Cobb, Sigal Fishman, Temuri Budagov, Lingguang Cui, Francine H Einstein, Aruna Poduval, David Hwang, Nir Barzilai, Pinchas Cohen   +12 more
doaj   +1 more source

Determinant Factors and Added Value of Osteoprotegerin (OPG) to Detect Carotid Intima-Media Thickness (CIMT) in Type 2 Diabetes Mellitus Patient

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Vascular calcification measured by carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (DM) patient is a predictor for cerebro-cardiovascular event.
Shirly Elisa Tedjasaputra, Em Yunir, Ika Prasetya Wijaya, Siti Setiati   +3 more
doaj   +1 more source

Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.

PLoS ONE, 2012
BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Teams   +11 more
doaj   +1 more source

干预代谢危险因素对脑血管病影响的研究进展

Zhongguo cuzhong zazhi
代谢危险因素是脑血管病的重要影响因素。随着代谢性脑血管病概念的提出，如何通过干预代谢危险因素改善此类患者的预后是未来重要的研究方向。代谢危险因素可相互影响并协同作用，降压、调脂、控制血糖等对传统代谢危险因素的干预可有效降低脑血管病的发病率和复发率；抗炎、补充维生素、调节肠道菌群等对残余代谢危险因素的干预同样是影响脑血管病发病及预后的重要措施。新型代谢药物“一专多能”的特点为代谢性脑血管病的治疗和管理提供了新的思路。本综述总结干预代谢危险因素对脑血管病影响的循证医学证据 ...
张方圆, 薛婧, 许杰, 王拥军 ZHANG Fangyuan, XUE Jing, XU Jie, WANG Yongjun
doaj   +1 more source

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

Journal of Lipid Research, 1997
Peroxisomal disorders arise either from defects in the biogenesis of peroxisomes or from the defective synthesis of one or more peroxisomal enzymes. These defects result in metabolic disturbances in peroxisomal beta-oxidation of various fatty acids and ...
Y Y van der Hoek, R J Wanders, A E van den Ende, H G Kraft, B R Gabel, J J Kastelein, M L Koschinsky   +6 more
doaj   +1 more source

Descrição atualizada da paralisia cerebral

Developmental Medicine &Child Neurology, EarlyView.
Resumo A paralisia cerebral (PC) é um termo descritivo amplamente utilizado para um espectro de deficiências motoras causadas por lesão ou malformação cerebral não progressiva ocorrida durante as fases iniciais do desenvolvimento. Avanços recentes nas áreas da genética, de pesquisa em inflamação e em neurofisiologia têm refinado a compreensão ...
Bernard Dan, Peter Rosenbaum, Lucinda Carr, Martin Gough, John Coughlan, Nonyelum Nweke   +5 more
wiley   +1 more source

残余代谢危险因素与青年卒中 Residual Metabolic Risk Factors and Stroke in Young Adults

Zhongguo cuzhong zazhi
青年卒中一般指在18～50岁年龄段内发生的卒中，其发病率上升给我国带来了日益增加的社会经济负担。在探讨青年卒中的代谢危险因素时，除了传统的高血压、糖代谢异常、脂代谢异常和肥胖外，残余代谢危险因素亦不容忽视。本文重点关注了炎症、高同型半胱氨酸血症、高尿酸血症和肠道微生物群代谢产物这4种残余代谢危险因素对青年卒中的影响。炎症在青年卒中中的作用显著，与心源性脑栓塞这一重要病因的发生发展密切相关。高同型半胱氨酸血症通过影响血管内皮和凝血功能促进血栓形成，是有望预测卒中风险及预后的重要指标 ...
钱宇彤1，2，张书凡1，2，韩振翔3，吴维诚4，韩翔1，2 (QIAN Yutong1,2, ZHANG Shufan1,2, HAN Zhenxiang3, WU Weicheng4, HAN Xiang1,2 )
doaj   +1 more source

Mini social cognition and emotional assessment: Diagnostic performance and neural correlates in behavioural‐variant frontotemporal dementia

Journal of Neuropsychology, EarlyView.
Abstract We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial Emotion Recognition Test (FERT) and the Faux Pas Test (FPT) measuring Theory of Mind (ToM) abilities in ...
Cem Doğdu, Neeraj Upadhyay, Ingo Frommann, Luca Kleineidam, Andreas Johnen, Melina Stark, Sandra Roeske, Annika Spottke, Anna Gamez, Gabor C. Petzold, Louise Droste zu Senden, Julian Hellmann‐Regen, Stefan Hetzer, Klaus Fliessbach, Carolin Miklitz, Emrah Düzel, Falk Lüsebrink, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Josef Priller, Eike Jakob Spruth, Johannes Prudlo, David Mengel, Klaus Scheffler, Matthis Synofzik, Anja Schneider, Michael Wagner   +27 more
wiley   +1 more source

Airway Involvement in Conradi–Hünermann–Happle Syndrome: A Novel Clinical Manifestation

The Laryngoscope, Volume 136, Issue 7, Page 3240-3245, July 2026.
We report the first documented case of airway involvement in Conradi–Hünermann–Happle syndrome (CDPX2), an X‐linked dominant form of chondrodysplasia punctata caused by pathogenic variants in EBP. A 2‐month‐old female with genetically confirmed CDPX2 developed severe subglottic stenosis and persistent respiratory distress requiring CPAP; cross ...
Enrique G. Villarreal, Jackie Chiang, Evan J. Propst, Nikolaus E. Wolter   +3 more
wiley   +1 more source

Improvement of Health‐Related Quality of Life and Mental Health After Unilateral Adrenalectomy for Primary Aldosteronism

Clinical Endocrinology, Volume 105, Issue 1, Page 24-33, July 2026.
ABSTRACT Background Primary aldosteronism (PA) has been linked with reduced health‐related quality of life (QoL) and increased prevalence of anxiety and depression. While most studies compared patients with PA to healthy subjects, this study focused on comparison with hypertensive patients without PA to identify PA‐specific effects.
Sybille Fuld, Christian Adolf, Georgiana Constantinescu, Manuel Schulze, Denise Brüdgam, Carmina T. Fuss, Hanna Remde, Lydia Kürzinger, Sven Gruber, Jun Yang, Amy Kang, Martin Reincke, Felix Beuschlein, Graeme Eisenhofer, Jacques W. M. Lenders, Christina Pamporaki   +15 more
wiley   +1 more source