Results 11 to 20 of about 3,218 (94)
Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder. [PDF]
J NeurochemAutism spectrum disorder (ASD) is diagnosed after behavioral symptoms emerge, highlighting the need for early biological markers, such as brain scans, genetic profiles, and biological samples from blood and urine tests, that could predict ASD before symptoms develop.
Wang BM +4 more
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Zhongguo cuzhong zazhi代谢性脑血管病以代谢危险因素引起的脑血管损害为核心，其概念已被提出并处于早期探索阶段。代谢性脑血管病的防治重点在于控制代谢危险因素，目前临床用药策略仍是对各个代谢危险因素进行单独干预，因用药种类多和剂量大给患者带来很多困扰。因此，临床亟需一种具有多作用靶点、可协同作用的药物以减少代谢性脑血管病患者的用药负担并提高疗效。牛磺酸作为一种条件必需氨基酸，具有调节糖脂代谢、调节渗透压、稳定细胞膜、抗氧化、抗衰老等多种生物学作用，对代谢性脑血管病治疗具有潜在临床价值。本文聚焦牛磺酸多效性 ...
温家琦1，2，庞江霞1，2，陈超1，2，姜长春1，2，郝喜娃1，2 (WEN Jiaqi1,2, PANG Jiangxia1,2, CHEN Chao1,2, JIANG Changchun1,2, HAO Xiwa1,2 )
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代谢组学在代谢性脑血管病中的应用研究 Application of Metabolomics in Cerebro-Metabolic Disease
Zhongguo cuzhong zazhi脑血管病是全球范围内导致人类死亡和残疾的主要原因，其中很高比例与代谢紊乱相关。代谢性脑血管病是指由传统代谢危险因素和残余代谢危险因素导致的脑血管损害，以血管结构受损及功能障碍为主要病理生理学表现，干预代谢危险因素可有效改善预后的一种临床综合征。代谢组学是采用高通量组学技术对所有代谢物进行鉴定和定量的手段，是未来研究代谢性脑血管病的重要抓手。本文总结了代谢组学、脂质组学在代谢性心脑血管疾病方面的研究，旨在为代谢性脑血管病的代谢组学研究开展及其临床防治提供参考。 Abstract ...
钟文华1，薛婧2，许杰1，2 ( ZHONG Wenhua1, XUE Jing2, XU Jie1,2 )
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Zhongguo cuzhong zazhi代谢性脑血管病是一个新近提出的概念，指由传统代谢危险因素和残余代谢危险因素引起的脑血管损害，通过干预代谢危险因素可有效改善其预后的一种临床综合征。代谢途径并非独立存在，脑、心脏、肝脏、肾脏和肠道等多个器官的各种代谢途径相互影响、共同作用、交织成网，构成了人体的代谢网络，而代谢网络的异常导致了代谢性脑血管病的发生。同时，代谢危险因素的存在可同时造成多个靶器官损害，且神经系统与心血管系统、内分泌系统、消化系统等可通过多种病理生理过程相互影响。因此 ...
许杰, 王拥军 XU Jie, WANG Yongjun
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肥胖相关慢性炎症与代谢性脑血管病 Obesity-Related Chronic Inflammation and Cerebro-Metabolic Disease
Zhongguo cuzhong zazhi脑血管病目前已成为全球第二大死亡原因，其发病风险主要归因于代谢紊乱。本文就肥胖相关慢性炎症与代谢性脑血管病的发病机制进行综述。肥胖状态下免疫细胞聚集、促炎因子分泌增加、血管内皮损伤等是代谢性脑血管病的重要致病机制。以炎症为治疗靶点的生活方式干预、药物免疫治疗及减重抗炎治疗等新型、有效的防治策略，有望为降低代谢性脑血管病的发病率，提高患者的生存率和生活质量提供参考依据。 Abstract: Cerebrovascular disease has become the second cause of ...
梁小雪, 郭黎 LIANG Xiaoxue, GUO Li
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Alteration of cleaner wrasse cognition and brain morphology under marine heatwaves
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Heatwaves, exacerbated by global warming, are progressively affecting various ecosystems, with coral reefs among the most susceptible. Within these ecosystems, cleaner wrasses (Labroides dimidiatus) engage in cooperative interactions with client fish by removing ...
Beatriz Pereira +3 more
wiley +1 more source
PLoS ONE, 2012 BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce +11 more
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Epilepsia, EarlyView.Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira +42 more
wiley +1 more source
Transcription‐coupled repair: tangled up in convoluted repair
The FEBS Journal, EarlyView.In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher +3 more
wiley +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT The bidirectional interaction between sleep and epilepsy is well known. In particular, it has been established that sleep apnea can worsen epilepsy, whereas sleep apnea (SA) treatment has a beneficial effect on seizure control. However, the exact mechanisms whereby SA promotes epileptic seizures are unknown.
Christian M. Horvath +4 more
wiley +1 more source