Results 21 to 30 of about 3,218 (94)

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science, Volume 12, Issue 25, July 3, 2025.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

Lipoprotein(a) levels in Down syndrome: A conundrum

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Lipoprotein a (Lp(a)) is a low‐density lipoprotein (LDL)‐like particle that has been associated with risk for vascular inflammation, atherogenesis, calcification, and thrombosis in the general population but is also a risk factor for Alzheimer disease (AD).
Herminia Diana Rosas, Florence Lai, Nathaniel Mercaldo   +2 more
wiley   +1 more source

Recent progress on nanotechnologies for enhancing blood‐brain barrier permeability

Smart Molecules, Volume 3, Issue 2, June 2025.
In this review, we summarize innovative strategies for harnessing the power of nanotechnology to enhance blood‐brain barrier permeability, a key challenge for central nervous system (CNS) drug delivery. We overview structural innovation of nanocarriers, improvements in targeting strategies, and nanotechnology‐enhanced brain imaging.
Qibin Liu, Zhuoqian Chen, Anthony Guiseppi‐Elie, Fanling Meng, Liang Luo   +4 more
wiley   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

The cerebellum in epilepsy

Epilepsia, Volume 66, Issue 6, Page 1773-1792, June 2025.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Cardiovascular Risk Factors Impact Brain Volume and White Matter Hyperintensities: A Multiethnic Cohort Study

Journal of Neuroimaging, Volume 35, Issue 3, May/June 2025.
ABSTRACT Background and Purpose Brain atrophy and white matter hyperintensities (WMHs) are established markers of cerebrovascular disease, yet most evidence comes from older populations of predominantly European descent. We prospectively examined the relationship between cardiovascular risk factors and brain volumes and WMHs in middle‐aged participants
Esther M. C. Vriend, Alexandra de Sitter, Thomas A. Bouwmeester, Oscar H. Franco, Henrike Galenkamp, Eric P. Moll van Charante, Didier Collard, Aart J. Nederveen, Bert‐Jan H. van den Born   +8 more
wiley   +1 more source

Reducing morbidity and mortality in high risk patients with statins

Vascular Health and Risk Management, 2009
Vibhuti Singh1, Prakash Deedwania21University of South Florida College of Medicine, and Suncoast Cardiovascular Center, St. Petersburg, Florida, USA; 2Cardiology Division, VACCHCS/UCSF, Fresno, CA, and UCSF School of Medicine, San Francisco, CA ...
Vibhuti Singh, Prakash Deedwania
doaj  

Effects of Cerebellar Transcranial Magnetic Stimulation on the Motor Function of Patients With Stroke: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 15, Issue 4, April 2025.
cTMS can effectively improve the motor function of patients with stroke, with significant efficacy in balance and limb motor function. The therapeutic effect of cTMS was more pronounced when intervening in the subacute phase, and when the excitatory stimulation mode and moderate intensity (≤ 80% RMT) were used.
Yongxin Zhu, Juncong Yang, Kun Wang, Xianwen Li, Jiahui Ling, Xie Wu, Lianhui Fu, Qi Qi   +7 more
wiley   +1 more source

Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background and Aims The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro‐cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in predicting MACCE and its individual components following ...
Abolfazl Salari, Parvin Kalhor, Ahmad Vakili‐Basir, Houshang Bavandpour Karvane, Mina Pashang, Mojgan Ghavami, Arash Jalali, Farshid Alaeddini, Farzad Masoudkabir   +8 more
wiley   +1 more source