Results 21 to 30 of about 19,079 (162)
Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]
, 2010 Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai +4 more
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Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]
, 2018 Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent +2 more
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Achievement of multiple therapeutic targets for cardiovascular disease prevention. Retrospective analysis of real practice in Italy [PDF]
, 2018 Background: Pharmacological therapy in patients at high cardiovascular (CV) risk should be tailored to achieve recommended therapeutic targets. Hypothesis: To evaluate individual global CV risk profile and to estimate the control rates of multiple ...
American Diabetes Association +33 more
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Hypertensive Disorders of Pregnancy and Future Cardiovascular Health. [PDF]
, 2020 Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations. These women are known to have higher cardiovascular morbidity and mortality later in life in comparison with parous controls who had normotensive pregnancies.
Giorgione, V +5 more
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Zhongguo cuzhong zazhi代谢危险因素是脑血管病的重要影响因素。随着代谢性脑血管病概念的提出，如何通过干预代谢危险因素改善此类患者的预后是未来重要的研究方向。代谢危险因素可相互影响并协同作用，降压、调脂、控制血糖等对传统代谢危险因素的干预可有效降低脑血管病的发病率和复发率；抗炎、补充维生素、调节肠道菌群等对残余代谢危险因素的干预同样是影响脑血管病发病及预后的重要措施。新型代谢药物“一专多能”的特点为代谢性脑血管病的治疗和管理提供了新的思路。本综述总结干预代谢危险因素对脑血管病影响的循证医学证据 ...
张方圆, 薛婧, 许杰, 王拥军 ZHANG Fangyuan, XUE Jing, XU Jie, WANG Yongjun
doaj +1 more source
Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]
, 2017 The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria +5 more
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Zhongguo cuzhong zazhi代谢性脑血管病以代谢危险因素引起的脑血管损害为核心，其概念已被提出并处于早期探索阶段。代谢性脑血管病的防治重点在于控制代谢危险因素，目前临床用药策略仍是对各个代谢危险因素进行单独干预，因用药种类多和剂量大给患者带来很多困扰。因此，临床亟需一种具有多作用靶点、可协同作用的药物以减少代谢性脑血管病患者的用药负担并提高疗效。牛磺酸作为一种条件必需氨基酸，具有调节糖脂代谢、调节渗透压、稳定细胞膜、抗氧化、抗衰老等多种生物学作用，对代谢性脑血管病治疗具有潜在临床价值。本文聚焦牛磺酸多效性 ...
温家琦1，2，庞江霞1，2，陈超1，2，姜长春1，2，郝喜娃1，2 (WEN Jiaqi1,2, PANG Jiangxia1,2, CHEN Chao1,2, JIANG Changchun1,2, HAO Xiwa1,2 )
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Research capacity and training needs for non-communicable diseases in the public health arena in Turkey [PDF]
, 2014 Background The aim of this study is to define the research capacity and training needs for professionals working on non-communicable diseases (NCDs) in the public health arena in Turkey.
Abu-Rmeileh, Niveen +7 more
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代谢组学在代谢性脑血管病中的应用研究 Application of Metabolomics in Cerebro-Metabolic Disease
Zhongguo cuzhong zazhi脑血管病是全球范围内导致人类死亡和残疾的主要原因，其中很高比例与代谢紊乱相关。代谢性脑血管病是指由传统代谢危险因素和残余代谢危险因素导致的脑血管损害，以血管结构受损及功能障碍为主要病理生理学表现，干预代谢危险因素可有效改善预后的一种临床综合征。代谢组学是采用高通量组学技术对所有代谢物进行鉴定和定量的手段，是未来研究代谢性脑血管病的重要抓手。本文总结了代谢组学、脂质组学在代谢性心脑血管疾病方面的研究，旨在为代谢性脑血管病的代谢组学研究开展及其临床防治提供参考。 Abstract ...
钟文华1，薛婧2，许杰1，2 ( ZHONG Wenhua1, XUE Jing2, XU Jie1,2 )
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Revista Médica Clínica Las Condes, 2017 RESUMEN: Debido al cambio demográfico de las últimas décadas, los sistemas de salud se han visto enfrentados a atender a pacientes cada vez de mayor edad.El Delirium Perioperatorio (DPO) es la más seria y más frecuente complicación cognitiva del paciente
Jimena Rodríguez, Dra.
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