Results 31 to 40 of about 19,079 (162)

Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study. [PDF]

, 2018
BackgroundThe p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease.MethodsTo expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males ...
Brand, Eva, Burlina, Alessandro, Cecchi, Franco, Garman, Scott C, Germain, Dominique P, Jovanovic, Ana, Kempf, Judy, Laney, Dawn A, Linhart, Aleš, Maródi, László, Nicholls, Kathy, Ortiz, Alberto, Pieruzzi, Federico, Shankar, Suma P, Waldek, Stephen, Wanner, Christoph   +15 more
core   +1 more source

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities : A Population Based Cohort Study [PDF]

, 2014
Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the ...
A Forsdahl, A Seidler, A Singhal, A Singhal, AD Murray, AD Murray, Alison D. Murray, B Dubois, B Galobardes, C Power, CB Wright, Christopher J. McNeil, CL Hart, DJ Barker, DJ Barker, GD Smith, H Soderlund, IB Meier, Lawrence J. Whalley, LJ Whalley, LM de Lau, MD Gliksman, MP Allin, O Grimaud, O Naess, P Scheltens, PJ Gianaros, PM Bentler, PM Bentler, Roger T. Staff, RT Staff, S Benisty, S Debette, S Salarirad, SD Shenkin, Sima Salarirad, Sonia Brucki, SP Wamala, T Delamothe   +38 more
core   +2 more sources

代谢性脑血管病的“多系统对话”与“多学科共管” “Multi-System Dialogue” and “Multi-Disciplinary Co-Management” of Cerebro-Metabolic Disease

Zhongguo cuzhong zazhi
代谢性脑血管病是一个新近提出的概念，指由传统代谢危险因素和残余代谢危险因素引起的脑血管损害，通过干预代谢危险因素可有效改善其预后的一种临床综合征。代谢途径并非独立存在，脑、心脏、肝脏、肾脏和肠道等多个器官的各种代谢途径相互影响、共同作用、交织成网，构成了人体的代谢网络，而代谢网络的异常导致了代谢性脑血管病的发生。同时，代谢危险因素的存在可同时造成多个靶器官损害，且神经系统与心血管系统、内分泌系统、消化系统等可通过多种病理生理过程相互影响。因此 ...
许杰, 王拥军 XU Jie, WANG Yongjun
doaj   +1 more source

肥胖相关慢性炎症与代谢性脑血管病 Obesity-Related Chronic Inflammation and Cerebro-Metabolic Disease

Zhongguo cuzhong zazhi
脑血管病目前已成为全球第二大死亡原因，其发病风险主要归因于代谢紊乱。本文就肥胖相关慢性炎症与代谢性脑血管病的发病机制进行综述。肥胖状态下免疫细胞聚集、促炎因子分泌增加、血管内皮损伤等是代谢性脑血管病的重要致病机制。以炎症为治疗靶点的生活方式干预、药物免疫治疗及减重抗炎治疗等新型、有效的防治策略，有望为降低代谢性脑血管病的发病率，提高患者的生存率和生活质量提供参考依据。 Abstract: Cerebrovascular disease has become the second cause of ...
梁小雪, 郭黎 LIANG Xiaoxue, GUO Li
doaj   +1 more source

Crossed cerebellar diaschisis in status epilepticus: A systematic review of the literature

Epileptic Disorders, EarlyView.
Abstract Objective Crossed cerebellar diaschisis is a neuroimaging phenomenon observed in various neurological conditions, including status epilepticus. This systematic review aims to summarize the clinical and radiological characteristics of patients developing crossed cerebellar diaschisis following status epilepticus and to discuss potential ...
Payam Tabaee Damavandi, Pilar Bosque‐Varela, Helena Barbosa Horta Santos, Bassam Al‐Fatly, Lukas Machegger, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source

Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.

PLoS ONE, 2012
BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Teams   +11 more
doaj   +1 more source

Postnatal anthropometric and body composition profiles in infants with intrauterine growth restriction identified by prenatal doppler [PDF]

, 2017
Introduction: Infant anthropometry and body composition have been previously assessed to gauge the impact of intrauterine growth restriction (IUGR) at birth, but the interplay between prenatal Doppler measurements and postnatal development has not been ...
Díaz, Marta, Gómez Roig, Ma. Dolores, Ibáñez Toda, Lourdes, Martinez-Cumplido, R., Mazarico Gallego, Edurne, Sebastiani, Giorgia   +5 more
core   +1 more source

Antidiabéticos orais. Como começar e combinar sem risco cardiovascular

Revista Portuguesa de Cardiologia, 2013
Resumo: A diabetes é, reconhecidamente, um importante factor de risco cardiovascular e a doença cárdio-cérebro vascular constitui a principal causa de mortalidade nas pessoas com diabetes.
Rui Duarte
doaj   +1 more source

Prevalence of disability according to multimorbidity and disease clustering: a population-based study [PDF]

, 2011
Background: The prevalence of chronic diseases has increased with population ageing, and research has attempted to elucidate the correlation between chronic diseases and disability. However, most studies in older populations have focused on the effect of
Angleman, Sara, Fratiglioni, Laura, Marengoni, Alessandra   +2 more
core   +1 more source

Regional cerebellar structural deficits distinguish psychostimulant‐free ADHD youth with and without familial risk for bipolar I disorder: a cross‐sectional morphometric analysis

Journal of Child Psychology and Psychiatry, EarlyView.
Background Although attention‐deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood.
Biqiu Tang, L. Rodrigo Patino, Wenjing Zhang, Su Lui, Melissa P. DelBello, Robert K. McNamara   +5 more
wiley   +1 more source