Results 121 to 130 of about 44,109 (276)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Numerical simulations of different models describing cerebrospinal fluid dynamics

, 2019
The aim of this paper is to present an extensive overview of numerical simulations aimed at confirming and completing the theoretical results obtained in the analysis of some cerebrospinal fluid dynamics models which are treated from a purely ...
Licia Romagnoli
core  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Cerebrospinal Fluid - Composition and Dynamics Across Contexts

Cerebrospinal fluid (CSF) offers a rare vantage point into the hidden chemistry of the brain. Its composition arises from a finely tuned balance of production, circulation, and interstitial exchange, regulated by ion homeostasis, transporter activity ...
Lyckenvik, Tim
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

Nature Communications
Brain waste is cleared via a cerebrospinal fluid (CSF) pathway, the glymphatic system, whose dysfunction may underlie many brain conditions. Previous studies show coherent vascular oscillation, measured by blood oxygenation level-dependent (BOLD) fMRI ...
Kai-Hsiang Chuang, Xiaoqing Alice Zhou, Ying Xia, Zengmin Li, Lei Qian, Eamonn Eeles, Grace Ngiam, Jurgen Fripp, Elizabeth J. Coulson   +8 more
doaj   +1 more source

Glymphatic MRI in idiopathic normal pressure hydrocephalus

, 2017
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer’s disease and brain ...
Eide, Per Kristian, Vatnehol, Svein Are Sirirud, Ringstad, Geir   +2 more
core   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Cerebrospinal fluid as an environment with radioprotective properties [PDF]

, 2014
Цереброспінальна рідина як гуморальне середовище головного мозку виконує важливу регуляторну функцію і є морфологічним субстратом, що об'єднує нервову, ендокринну та імунну системи. У статті описана морфологія червоного кісткового мозку, гіпофіза і
Олейникова, О.К., Бессалова, Е.Ю., Какура, С.И., Пикалюк, В.С., Абсеттарова, А.И.   +4 more
core