Results 121 to 130 of about 1,400,457 (288)
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Multi‐omics–driven precision medicine
iMeta, EarlyView.Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li +20 more
wiley +1 more source
iNew Medicine, EarlyView.This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin +10 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang +8 more
wiley +1 more source
What does an isolated cerebrospinal fluid band mean: a tertiary centre experience
, 2015 Introduction: The presence of oligoclonal bands in cerebrospinal fluid of multiple sclerosis patients is now well established to support the clinical diagnosis. On the other hand, a single band response can represent the initial stage of an oligoclonal
Turan Poyraz +11 more
core +1 more source
Autologous Mastoid Cortex Bone Graft for Multilayer Repair of Lateral Skull Base Defects
The Laryngoscope, EarlyView.Multilayer repair of lateral skull base cerebrospinal fluid leaks and encephaloceles can be reinforced with rigid autologous grafts. Harvesting a monocortical mastoid cortex bone graft is effective and easy to implement without conferring additional morbidity.
Christopher Z. Wen +5 more
wiley +1 more source
Cranial Vault and Scalp Reconstruction Utilizing Anterolateral Thigh Free Tissue Transfer
The Laryngoscope, EarlyView.The anterolateral thigh free flap with perforator harvest and minimal access recipient vessel procurement technique offers an adaptable and effective reconstructive option for a wide variety of complex scalp and cranial vault defects. There were no significant differences in outcomes or complications of the three flap types analyzed (fasciocutaneous ...
Conrad Blunck +7 more
wiley +1 more source
Vocal Fold Atrophy in Patients With Alzheimer's Disease and Related Dementias
The Laryngoscope, EarlyView.This is the first study to quantify vocal fold atrophy in patients with Alzheimer's disease and related dementias (AD/ADRD) using endoscopic imaging. Compared with age‐matched controls, AD/ADRD patients showed significantly greater vocal fold bowing and reduced mucosal wave amplitude, while normalized glottal gap area did not differ.
Byron Kim +5 more
wiley +1 more source
Cerebrospinal fluid leakage after elective disc surgery
, 2012 For patients undergoing elective disc herniation surgery the risk to experience a dural tear is somewhere around 1% both for the cervical and the thoracic regions and probably slightly higher for the lumbar region. In most cases a dural tear is diagnosed
Brisby, Helena,, Baranto, Adad,
core +1 more source