Results 101 to 110 of about 445,834 (292)

Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report

BMC Neurology, 2018
Background Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition.
Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki   +4 more
doaj   +1 more source

Measuring cerebrovascular reactivity: what stimulus to use? [PDF]

, 2013
Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between different regions of the brain has the potential to not only advance ...
Crawley, A P, Mikulis, D J, Fierstra, J, Battisti-Charbonney, A, Duffin, J, Fisher, J A, Poublanc, J, Sobczyk, O, Mandell, D M   +8 more
core   +1 more source

Prediction of Long‐Term Prognosis in Patients With Hepatocellular Carcinoma Using the National Clinical Database Risk Calculator

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to determine the value of the National Clinical Database (NCD) risk calculator in predicting surgical outcomes and long‐term prognosis in patients undergoing resection for hepatocellular carcinoma (HCC). We retrospectively analyzed data from 210 patients with HCC who underwent initial hepatic resection, assessing the relationship ...
Mariko Tsukagoshi, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Shunsuke Kawai, Kei Hagiwara, Kouki Hoshino, Ryo Muranushi, Ken Shirabe   +8 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Transcranial Doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture [PDF]

, 2013
Transcranial Doppler ultrasound (TCD) allows measurement of blood flow velocities in the intracranial vessels, and can be used to assess cerebral vasodilator responses to a hypercapnic stimulus. The reliability of this technique has not been established,
Mark A. Cutting, Jonathan D. Buckley, McDonnell, Michelle N., Michelle N. McDonnell, Berry, N., Peter R.C. Howe, Buckley, J., Keage, Hannah A., Hannah A. Keage, Howe, Peter R. C., Buckley, Jonathan D., Keage, H., McDonnell, M., Howe, P., Cutting, Mark A., Narelle M. Berry, Cutting, M., Berry, Narelle M.   +17 more
core   +2 more sources

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Cerebrovascular reactivity to hypercapnia in patients with migraine: a dual-echo arterial spin labeling MRI study

ObjectiveThis study aimed to compare cerebrovascular reactivity between patients with migraine and controls using state-of-the-art magnetic resonance imaging (MRI) techniques.BackgroundMigraine is associated with an increased risk of cerebrovascular ...
Osch, M.J.P. van, Dahan, A., Pelzer, N., Ghariq, E., Hoogeveen, E.S., Terwindt, G.M., Kruit, M.C.   +6 more
core   +1 more source

Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity

, 1999
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the possibility of obtaining prognostic indications in patients with internal carotid occlusion on the basis of intracranial hemodynamic status, presence of previous symptoms of ...
SILVESTRINI, Mauro, PASQUALETTI P, VERNIERI F, PASSARELLI F, ROSSINI PM   +4 more
core   +2 more sources

CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

JACC: Basic to Translational Science, 2019
Summary: Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conductance
Darcy Lidington, PhD, Jessica C. Fares, MSc, Franziska E. Uhl, PhD, Danny D. Dinh, MSc, Jeffrey T. Kroetsch, PhD, Meghan Sauvé, PhD, Firhan A. Malik, PhD, Frank Matthes, PhD, Lotte Vanherle, MSc, Arman Adel, BSc, Abdul Momen, MD, PhD, Hangjun Zhang, MD, Roozbeh Aschar-Sobbi, PhD, Warren D. Foltz, PhD, Hoyee Wan, BSc, Manabu Sumiyoshi, MD, R. Loch Macdonald, MD, PhD, Mansoor Husain, MD, Peter H. Backx, PhD, DVM, Scott P. Heximer, PhD, Anja Meissner, PhD, Steffen-Sebastian Bolz, MD, PhD   +21 more
doaj   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source