Results 111 to 120 of about 445,834 (292)

Healthy aging affects cerebrovascular reactivity and pressure-flow responses, but not neurovascular coupling: A cross-sectional study.

PLoS ONE, 2019
Background and purposeAging leads to alterations in cerebrovascular function, and these are thought to contribute to cognitive decline/dementia. Disturbances to cerebral blood flow regulation have been reported, but the findings are inconsistent and to ...
Kayla B Stefanidis, Christopher D Askew, Timo Klein, Jim Lagopoulos, Mathew J Summers   +4 more
doaj   +1 more source

Loneliness, social support and cardiovascular reactivity to laboratory stress [PDF]

, 2007
Self-reported or explicit loneliness and social support have been inconsistently associated with cardiovascular reactivity (CVR) to stress. The present study aimed to adapt an implicit measure of loneliness, and use it alongside the measures of explicit ...
Gidron, Y.Y., Nausheen, Bina, Gregg, A., Peveler, L., Peveler, Robert, Nausheen, B., Tissarchondou, Harilaos S., Gregg, Aiden, Tissarchondou, H., Gidron, Yori   +9 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

TREM2-regulated microglial reactivity confers resilience against vascular contributions to white matter injury and cognitive decline

Cerebral Circulation - Cognition and Behavior
Cerebrovascular disease is a major contributor to subcortical white matter pathology, vascular cognitive impairment (VCI) and dementia. Although the precise pathophysiological mechanisms remain unclear, it is increasingly evident that microglial ...
Stefan Szymkowiak, Mila Redzic, Anirudh Patir, Clare Latta, Michael Daniels, Jack Barrington, Katie Askew, Jessica Duncombe, Karen Horsburgh, Barry McColl   +9 more
doaj   +1 more source

Acute hyperglycemia reduces cerebrovascular reactivity: The role of glycemic variability

, 2014
Cerebral vasomotor reactivity (CVR) is reduced in patients with diabetes mellitus (DM), and glucose variability (GV) might be responsible for cerebrovascular ...
Donno, S, Palazzo, P, Lauro, D, Altavilla, R, Di Flaviani, A, Giordani, I, Picconi, F, Pasqualetti, P, FRONTONI, SIMONA, Vernieri, F, LAURO, DAVIDE, Ylli, D, Malandrucco, I, Frontoni, S, Passarelli, F   +14 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Non-invasive bio-electromagnetic monitoring of cerebrovascular function: a novel conductivity reactivity index (CRx) for optimal cerebral perfusion pressure in acute brain injury models

Frontiers in Bioengineering and Biotechnology
IntroductionThe pressure reactivity index (PRx) is a key predictor of cerebrovascular function, widely used to guide and optimize therapeutic strategies in patients with acute brain injury.
Jia Xu, Haochen Li, Feng Wang, Lian Yan, Gui Jin, Mingsheng Chen, Gen Li, Mingxin Qin   +7 more
doaj   +1 more source

Drug‐Coated Balloon‐Based Strategy for De Novo Coronary Artery Disease Across Complex and High‐Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Evidence regarding the risk‐stratified effectiveness of drug‐coated balloon (DCB)‐based PCI for de novo coronary artery disease (CAD) remains limited, particularly in patients undergoing complex and high‐risk indicated percutaneous coronary intervention (CHIP PCI).
Dong Oh Kang, Sunwon Kim, Ae‐Young Her, Eun‐Seok Shin   +3 more
wiley   +1 more source

Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

, 2018
Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy ...
Helen Macpherson (13082655), ME Hughes (14547761), TB Parrish (15822692), Y Chen (5099375), SJ Catchlove (14547758), A Pipingas (9630335)   +5 more
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