Development of a Complex Intervention to Support the Use of Sedative Drugs in Specialist Palliative Care (iSedPall) [PDF]
Palliative Medicine ReportsBackground: The option of intentional sedation to relieve intolerable suffering from treatment-refractory symptoms may elicit a feeling of safety for patients and informal caregivers as a last resort if the situation becomes unbearable.
Saskia Kauzner +15 more
doaj +4 more sources
“We don’t want to sedate him” - A qualitative interview study on intentions when administering sedative drugs at the end of life in nursing homes and hospitals [PDF]
BMC Palliative Care, 2021 Background Previous data indicate major differences between countries and settings regarding the intention when administering sedative drugs at the end of life and the perception, which drugs are sedating.
Sophie Meesters +3 more
doaj +2 more sources
Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study [PDF]
Scientific Reports, 2021 Our aim was to evaluate maternal use of sedative drugs before, during, and after pregnancy and to assess the influence of use of these drugs on pregnancy outcomes.
Satu-Maarit Björkstedt +6 more
doaj +2 more sources
Use of sedative drugs in specialist palliative care (iSedPall): a multi-modal intervention pilot study protocol [PDF]
Pilot and Feasibility StudiesBackground The use of sedative drugs in specialist palliative care is common but presents challenges due to specific medical, ethical, and legal considerations.
Christoph Ostgathe +13 more
doaj +2 more sources
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs [PDF]
Current Issues in Molecular BiologyA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized.
Katharina Haller +2 more
doaj +2 more sources
Impact of cumulative exposure to anticholinergic and sedative drugs on cognition in older adults: a memory clinic cohort study [PDF]
Alzheimer’s Research & TherapyBackground Long-term exposure to anticholinergic and sedative drugs could be a modifiable risk factor for cognitive decline. The objective of this study was to measure the association between previous cumulative anticholinergic and sedative drug exposure
Elsa Reallon +9 more
doaj +2 more sources
Neurotrauma Reports, 2020 The impact of vasopressor and sedative drugs on cerebrovascular reactivity in traumatic brain injury (TBI) remains unclear. The aim of this study was to evaluate the impact of changes of doses of commonly administered sedation (i.e., propofol, fentanyl ...
Logan Froese +6 more
doaj +3 more sources
Saudi Pharmaceutical Journal, 2023 Background: This study aimed to investigate the trend of hospital admissions related to poisoning by narcotics and psychodysleptics and poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism drugs in England and Wales between April 1999 and ...
Hassan Alwafi
doaj +1 more source
New sedatives and analgesic drugs for gastrointestinal endoscopic procedures [PDF]
Clinical Endoscopy, 2022 Procedural sedation has become increasingly common in endoscopy. Sedatives and analgesics induce anxiolysis and amnesia. In addition, an appropriate level of sedation is necessary for safe procedures including therapeutic endoscopy.
Jae Min Lee +12 more
doaj +1 more source
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment. [PDF]
PLoS ONE, 2012 Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes.We investigated tolerance to acute anxiolytic ...
Christiaan H Vinkers +7 more
doaj +1 more source