Results 81 to 90 of about 32,185 (293)

Cerebrovascular reactivity mapping using intermittent breath modulation

NeuroImage, 2020
Cerebrovascular reactivity (CVR), an index of brain vessel’s dilatory capacity, is typically measured using hypercapnic gas inhalation or breath-holding as a vasoactive challenge.
Peiying Liu, Cuimei Xu, Zixuan Lin, Sandeepa Sur, Yang Li, Sevil Yasar, Paul Rosenberg, Marilyn Albert, Hanzhang Lu   +8 more
doaj   +1 more source

Cerebrovascular pulsatility index is higher in chronic kidney disease

Physiological Reports, 2023
Patients with chronic kidney disease (CKD) are more likely to die of cardiovascular diseases, including cerebrovascular disease, than to progress to end‐stage kidney disease.
Ester S. Oh, Kaitlin A. Freeberg, Cortney N. Steele, Wei Wang, Heather Farmer‐Bailey, McKinley E. Coppock, Douglas R. Seals, Michel Chonchol, Matthew J. Rossman, Daniel H. Craighead, Kristen L. Nowak   +10 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Course of cerebrovascular reactivity in patients with carotid artery occlusions.

, 1994
Patients with internal carotid artery occlusions and highly impaired cerebrovascular reactivity have been identified as having an increased risk of stroke.
B Kleiser, H Krapf, B Widder
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Intracranial and Extracranial Injury Burden as Drivers of Impaired Cerebrovascular Reactivity in Traumatic Brain Injury.

, 2018
Impaired cerebrovascular reactivity has been associated with outcome following traumatic brain injury (TBI), but it is unknown how it is affected by trauma severity.
Joseph Donnelly, Peter Smielewski, Marek Czosnyka, Basil Nourallah, Eric P. Thelin, Leanne Calviello, Frederick A. Zeiler, Ari Ercole, David K. Menon   +8 more
core   +1 more source

Effect of Lactulose on the Intestinal Flora of Elderly Constipation Patients With Chronic Renal Insufficiency

AGING MEDICINE, EarlyView.
This study investigates the regulatory effects of lactulose and polyethylene glycol (PEG) on the composition of gut microbiota in elderly constipation patients with chronic renal insufficiency by comparing the changes in microbial abundance. Both lactulose and PEG significantly modulate the gut microbiota structure, though their specific mechanisms and
Jianxia Ma, Jun Wang, Tianran Han, Zhifang Shao, Weiqi Zhang, Ke Wang, Qinlian Zeng, Kangwei Liu, Yuanwen Chen, Songbai Zhen, Jianfeng Yao   +10 more
wiley   +1 more source

A high salt meal does not impair cerebrovascular reactivity in healthy young adults

Physiological Reports, 2020
A high sodium (Na+) meal impairs peripheral vascular function. In rodents, chronic high dietary Na+ impairs cerebral vascular function, and in humans, habitual high dietary Na+ is associated with increased stroke risk.
Kamila U. Migdal, Austin T. Robinson, Joseph C. Watso, Matthew C. Babcock, Shannon L. Lennon, Christopher R. Martens, Jorge M. Serrador, William B. Farquhar   +7 more
doaj   +1 more source

Risks and Benefits of Feeding Enterostomy Creation During Minimally Invasive Esophagectomy: A Propensity‐Weighted Analysis Using the Japanese National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
Feeding enterostomy during MIE was evaluated in 19 054 patients from the Japanese NCD using propensity weighting. Enterostomy was associated with higher reoperation and respiratory complications, but lower delayed gastric emptying and deep vein thrombosis, with no significant difference in overall bowel obstruction.
Eisuke Booka, Shinya Hirakawa, Hisateru Tachimori, Koji Tanaka, Hideki Ueno, Yasue Kimura, Ken Shirabe, Hiroya Takeuchi   +7 more
wiley   +1 more source