Results 71 to 80 of about 32,185 (293)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Cerebrovascular Reactivity Remains Intact after Cortical Depolarization in Newborn Piglets

, 2023
Cerebrovascular reactivity is severely affected by ischemia, and changes in vascular responses have been reported after cortical spreading depression and head trauma as well.
Busija, David W., Louis, Thomas M., NC DOCKS at East Carolina University, Veltkamp, Roland, Domoki, Ferenc, Bari, Ferenc   +5 more
core  

DataSheet1_Dynamic Temporal Relationship Between Autonomic Function and Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury.DOCX

, 2022
There has been little change in morbidity and mortality in traumatic brain injury (TBI) in the last 25 years. However, literature has emerged linking impaired cerebrovascular reactivity (a surrogate of cerebral autoregulation) with poor outcomes post ...
Arsalan Alizadeh (4873996), Kevin Stein (12095300), Logan Froese (11080806), Alwyn Gomez (11080803), Amanjyot Singh Sainbhi (11080809), Frederick A. Zeiler (5840711), Carleen Batson (11080812)   +6 more
core   +1 more source

Leveraging Function Intersectionality and Multi-Modal Cerebrovascular Reactivity Measures for the Derivation of Individualized Intracranial Pressure Thresholds in Acute Traumatic Neural Injury

Bioengineering
It has been proposed that subject-specific intracranial pressure (ICP) thresholds can be feasibly derived using the relationship between cerebrovascular reactivity and ICP.
Kevin Y. Stein, Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Abrar Islam, Tobias Bergmann, Frederick A. Zeiler   +7 more
doaj   +1 more source

Near-Infrared Cerebrovascular Reactivity for Monitoring Cerebral Autoregulation and Predicting Outcomes in Moderate to Severe Traumatic Brain Injury: Proposal for a Pilot Observational Study

JMIR Research Protocols, 2020
BackgroundImpaired cerebrovascular reactivity after traumatic brain injury (TBI) in adults is emerging as an important prognostic factor, with strong independent association with 6-month outcomes.
Gomez, Alwyn, Dian, Joshua, Froese, Logan, Zeiler, Frederick Adam   +3 more
doaj   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

, 2005
The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was ...
Ferrante, F, DIOMEDI, MARINA, Rizzato, B, Spera, E, Leone, G, SPERA, ENRICO, BERNARDI, GIORGIO, Sallustio, F, Diomedi, M, Bernardi, G., Scarfini, M   +10 more
core   +1 more source

DataSheet7_Dynamic Temporal Relationship Between Autonomic Function and Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury.DOCX

, 2022
There has been little change in morbidity and mortality in traumatic brain injury (TBI) in the last 25 years. However, literature has emerged linking impaired cerebrovascular reactivity (a surrogate of cerebral autoregulation) with poor outcomes post ...
Arsalan Alizadeh (4873996), Kevin Stein (12095300), Logan Froese (11080806), Alwyn Gomez (11080803), Amanjyot Singh Sainbhi (11080809), Frederick A. Zeiler (5840711), Carleen Batson (11080812)   +6 more
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

DataSheet6_Dynamic Temporal Relationship Between Autonomic Function and Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury.DOCX

, 2022
There has been little change in morbidity and mortality in traumatic brain injury (TBI) in the last 25 years. However, literature has emerged linking impaired cerebrovascular reactivity (a surrogate of cerebral autoregulation) with poor outcomes post ...
Arsalan Alizadeh (4873996), Kevin Stein (12095300), Logan Froese (11080806), Alwyn Gomez (11080803), Amanjyot Singh Sainbhi (11080809), Frederick A. Zeiler (5840711), Carleen Batson (11080812)   +6 more
core   +1 more source