Results 51 to 60 of about 29,744 (154)

CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

JACC: Basic to Translational Science, 2019
Summary: Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conductance
Darcy Lidington, PhD, Jessica C. Fares, MSc, Franziska E. Uhl, PhD, Danny D. Dinh, MSc, Jeffrey T. Kroetsch, PhD, Meghan Sauvé, PhD, Firhan A. Malik, PhD, Frank Matthes, PhD, Lotte Vanherle, MSc, Arman Adel, BSc, Abdul Momen, MD, PhD, Hangjun Zhang, MD, Roozbeh Aschar-Sobbi, PhD, Warren D. Foltz, PhD, Hoyee Wan, BSc, Manabu Sumiyoshi, MD, R. Loch Macdonald, MD, PhD, Mansoor Husain, MD, Peter H. Backx, PhD, DVM, Scott P. Heximer, PhD, Anja Meissner, PhD, Steffen-Sebastian Bolz, MD, PhD   +21 more
doaj   +1 more source

Healthy aging affects cerebrovascular reactivity and pressure-flow responses, but not neurovascular coupling: A cross-sectional study.

PLoS ONE, 2019
Background and purposeAging leads to alterations in cerebrovascular function, and these are thought to contribute to cognitive decline/dementia. Disturbances to cerebral blood flow regulation have been reported, but the findings are inconsistent and to ...
Kayla B Stefanidis, Christopher D Askew, Timo Klein, Jim Lagopoulos, Mathew J Summers   +4 more
doaj   +1 more source

TREM2-regulated microglial reactivity confers resilience against vascular contributions to white matter injury and cognitive decline

Cerebral Circulation - Cognition and Behavior
Cerebrovascular disease is a major contributor to subcortical white matter pathology, vascular cognitive impairment (VCI) and dementia. Although the precise pathophysiological mechanisms remain unclear, it is increasingly evident that microglial ...
Stefan Szymkowiak, Mila Redzic, Anirudh Patir, Clare Latta, Michael Daniels, Jack Barrington, Katie Askew, Jessica Duncombe, Karen Horsburgh, Barry McColl   +9 more
doaj   +1 more source

Non-invasive bio-electromagnetic monitoring of cerebrovascular function: a novel conductivity reactivity index (CRx) for optimal cerebral perfusion pressure in acute brain injury models

Frontiers in Bioengineering and Biotechnology
IntroductionThe pressure reactivity index (PRx) is a key predictor of cerebrovascular function, widely used to guide and optimize therapeutic strategies in patients with acute brain injury.
Jia Xu, Haochen Li, Feng Wang, Lian Yan, Gui Jin, Mingsheng Chen, Gen Li, Mingxin Qin   +7 more
doaj   +1 more source

Sevoflurane-induced hemispheric cerebral blood flow reduction in mice with revived global perfusion after carotid artery occlusion

European Journal of Medical Research
Background Carotid artery disease (CAD) presents a significant risk for ischemic stroke. Understanding the pathophysiological changes following carotid artery occlusion, particularly regarding cerebral blood flow (CBF) and cerebrovascular reactivity (CVR)
Rui Hao, Juchen Li, Jing Cang, Fang Fang
doaj   +1 more source

Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study

Journal of Cerebral Blood Flow & Metabolism
A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson’s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy ...
van der Horn, Harm Jan, Vakhtin, Andrei A, Julio, Kayla, Nitschke, Stephanie, Shaff, Nicholas, Dodd, Andrew B, Erhardt, Erik, Phillips, John P, Pirio Richardson, Sarah, Deligtisch, Amanda, Stewart, Melanie, Suarez Cedeno, Gerson, Meles, Sanne K, Mayer, Andrew R, Ryman, Sephira G   +14 more
openaire   +2 more sources

Evaluation of cerebrovascular reactivity in moyamoya disease using oxygen-dependent magnetic resonance imaging

iScience
Summary: Moyamoya disease (MMD) is a rare cerebrovascular disorder marked by progressive stenosis of the internal carotid arteries. Assessing cerebral hemodynamics, specifically cerebrovascular reactivity (CVR), is vital for MMD management and prognosis.
Shihao He, Xilong Wang, Hongchuan Niu, Ziqi Liu, Junze Zhang, Xiaokuan Hao, Yanru Wang, Zhenyu Zhou, Yuanli Zhao, Rong Wang   +9 more
doaj   +1 more source

The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and is a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies in T2D disregarded the impact of impaired CVR ...
Yarden Oliel, Ramit Ravona‐Springer, Maayan Harel, Joseph Azuri, Chen Botvin Moshe, David Tanne, Salo Haratz, Barbara B Bendlin, Michal Schnaider Beeri, Abigail Livny   +9 more
doaj   +1 more source

Cerebrovascular reactivity in migraine: a breath-hold BOLD fMRI study

The Journal of Headache and Pain
Background and objectives Prior studies assessing cerebrovascular reactivity (CVR) in participants with migraine primarily utilized Doppler ultrasonography and focused on large vascular territories due to limitations of available technology.
Adam S. Sprouse Blum, Richard Watts, Scott G. Hipko, Jay V. Gonyea, Anna E. Senft-Miller, Olivia K. Nop, Julie A. Dumas, Robert E. Shapiro, Benjamin Littenberg, Bruno P. Soares, Lauren A. DaSilva, James B. Allison, Josh E. Furlonge, Jiming Zhang   +13 more
doaj   +1 more source

Hypothermia and cerebrovascular reactivity [PDF]

British Journal of Anaesthesia, 2007
openaire   +1 more source