Results 291 to 300 of about 101,605 (316)

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Reviews in Medical Virology
A significant portion of human cancers are caused by oncoviruses (12%–25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the ...
M. Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, A. Daraei   +8 more
semanticscholar   +1 more source

Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma

Molecular BioSystems, 2015
The dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma.
Juan Xu, Tingting Shao, Juan Chen, Yongsheng Li, Aiwei Wu, Xia Li, Hong Chen, Jianping Lu, Jing Bai   +8 more
openaire   +3 more sources

Studying the Oncosuppressive Functions of PTENP1 as a ceRNA

2021
PTENP1 is a processed pseudogene of the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN). It functions posttranscriptionally to regulate PTEN by acting as a sponge for microRNAs that target PTEN. PTENP1 therefore functions as a competitive endogenous RNA (ceRNA), competing with PTEN for binding of microRNAs (miRNA) and ...
Nahal Haddadi, Eileen M. McGowan, Ann M. Simpson, Najah T. Nassif, Glena Travis, Deborah J. Marsh, Deborah J. Marsh   +6 more
openaire   +3 more sources

Remarks by Christina Cerna

Proceedings of the ASIL Annual Meeting, 2019
I am pleased and honored to be chairing this panel this morning. Regrettably, Fatsah Ouguergouz of the African Court of Human and Peoples' Rights had a death in the family and had to travel to Algeria and could not be with us today.
openaire   +2 more sources

PTEN ceRNA networks in human cancer

Methods, 2015
In multiple human cancer types, a close link exists between the expression levels of Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN) and its oncosuppressive activities. Therefore, an in depth understanding of the molecular mechanisms by which PTEN expression is modulated is crucial in order to achieve a comprehensive knowledge of its ...
Poliseno L, Pandolfi PP
openaire   +4 more sources

ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications

Blood, 2013
Abstract We will discuss exciting new data regarding the role of pseudogenes, long intergenic non-coding RNAs (lincRNAs) and miRNAs in the pathogenesis of leukemia and lymphoma, as also studied in vivo in the mouse, and their therapeutic implications.
openaire   +2 more sources

LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

Molecular Cancer, 2018
Gastric cancer (GC) is a common malignancy and frequent cause of cancer-related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators and tissue-specific biomarkers of multiple cancers, including GC.
Shu-Zhong Cui
exaly   +2 more sources

Caves of Cerna Valley

2018
Over 300 dry (fossil) and active (stream) caves of thermal and hypogene origin are known in the upper Cerna Valley, between Naiba Valley and Pecinișca Village. The large variety of caves is sustained by a complex geology developed along the graben, with granites outcropping along the Cerna River’s thalweg.
openaire   +2 more sources

circEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma

Current Cancer Drug Targets, 2020
Background: Recent studies have reported the vital roles of circular RNAs (circRNAs) in tumor progression. However, the function and expression profile of most circRNAs in osteosarcoma remain unclear. Methods: We examined the expression of circEPSTI1, a circRNA, in 50 paired adjacent normal tissues and osteosarcoma tissues by qRT-PCR.
Duxun Tan, Ye Lin, Wen Zhishen, Haomiao Li, Tan Xinyu, Canjun Zeng   +5 more
openaire   +2 more sources

Computational Identification of Cross-Talking ceRNAs

2018
Competing endogenous RNAs (ceRNAs) are kinds of RNAs that regulate each other at post-transcription level through competing for miRNA regulators. CeRNA-ceRNA networks provide another type of function for protein-coding mRNAs, which link non-coding RNAs such as miRNA, long non-coding RNA, pseudogenes and circular RNAs. In this chapter, we will introduce
Xiaoyu Lin, Caiqin Huo, Yongsheng Li, Juan Xu   +3 more
openaire   +2 more sources