From Radiocopper to Cold Copper: Mechanistic Modeling and Simulation to Define Clinical Response Criteria and Biomarkers for VTX-801 in Wilson Disease. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT We developed a comprehensive, mechanistic model of human copper metabolism to support biomarker qualification for VTX‐801, an adeno‐associated vector‐based gene therapy which is being developed to restore the mutated ATP7B copper transporter gene in Wilson disease (WD). The model integrates physiological copper kinetics with pathophysiological
Lindauer A +3 more
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Study of serum ceruloplasmin and zinc in type 2 diabetes mellitus
Zanco Journal of Medical Sciences, 2021 Background and objective: Ceruloplasmin is the major copper-carrying protein in the blood and plays a role in iron metabolism. Zinc is an essential trace element for human health, which activates about 200 enzymes.
Amanj Zrar Hasan +2 more
doaj +1 more source
Ceruloplasmin as a Vital Tool for Grading of Preeclampsia: A Case-Control Study in Central India.
J Pharm Bioallied SciRaghuwanshi K +5 more
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Ibn Al-Haitham Journal for Pure and Applied Sciences, 2021 Ceruloplasmin is considered the main copper transport protein which is proposed to have a role in cancer. Ceruloplasmin is an acute phase reactant and antioxidant enzyme, has been found to be increased in sera of patients with several types of cancers ...
Shahlaa Shafiq Rozoqi
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Heliyon, 2023 Neural and cognitive processes require zinc and copper homeostasis and a normal zinc/copper ratio. Ceruloplasmin, an intrinsic antioxidant protein, maintains copper homeostasis, which might also influence autism spectrum disorder (ASD).
Umme Raihan Siddiqi +6 more
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DIAGNOSTIC VALUE OF CERULOPLASMIN IN SYSTEMIC SCLERODERMA
Медицинская иммунология, 2019 Objective of study: refining immune diagnostics of systemic scleroderma through determining ceruloplasmin antibodies, its amount and enzymatic activity, as well as control of effectiveness of therapy with ceruloplasmin-based immobilized ...
O. I. Emelyanova +3 more
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Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells. [PDF]
PLoS ONE, 2016 Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role in efflux of iron from cells, but has additional functions.
Danny Ramos +6 more
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Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients
Biomarker Insights, 2006 A dysfunction in copper homeostasis seems to occur in Alzheimer's disease (AD). We previously evidenced that an excess of non-ceruloplasmin-copper (NCC) correlated with the main functional, anatomical as well as cerebrospinal markers of the disease.
Rosanna Squitti +7 more
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Determination of ceruloplasmin, some other acute phase proteins, and biochemical parameters in cows with endometritis [PDF]
Veterinary World, 2016 Aim: The aim of this study is to determine serum ceruloplasmin levels in cows with endometritis of varying degrees of severity and to establish whether or not there is a correlation between acute phase protein (APP) levels and biochemical parameters ...
S. Kaya +4 more
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Apoceruloplasmin: Abundance, Detection, Formation, and Metabolism
Biomedicines, 2021 Ceruloplasmin, the main copper-binding protein in blood and some other fluids, is well known for its copper-dependent enzymatic functions and as a source of copper for cells.
Maria C. Linder
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