Results 11 to 20 of about 24,157 (174)

Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia

EMBO Molecular Medicine, 2017
Aceruloplasminemia is a monogenic disease caused by mutations in the ceruloplasmin gene that result in loss of protein ferroxidase activity. Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver ...
Alan Zanardi, Antonio Conti, Marco Cremonesi, Patrizia D'Adamo, Enrica Gilberti, Pietro Apostoli, Carlo Vittorio Cannistraci, Alberto Piperno, Samuel David, Massimo Alessio   +9 more
doaj   +2 more sources

Therapeutic Reversal of Severe Neuropsychiatric Symptoms in Wilson's Disease: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Wilsons disease is an autosomal recessive genetic disorder of copper metabolism that results in copper accumulation in liver and other organs. Hepatic manifestation tends to occur earlier than the neurological manifestation. We present a case with psychiatric presentation.
Penjor T, Dorji S, Wangchuk S.
europepmc   +2 more sources

Copper-Induced Oligomerization of Ceruloplasmin

, 2021
Oligomerization of copper-containing ferroxidase of ceruloplasmin in the presence of protein-unbound copper in a solution has been investigated by small-angle X-ray scattering (SAXS). Ceruloplasmin is a monomer with a molecular weight of ~132 kDa. Copper
Petoukhov, M. V., Kostevich, V. A., Samygina, V. R., Sokolov, A. V., V. R. Samygina, A. V. Sokolov, M. V. Petoukhov, V. A. Kostevich   +7 more
core   +1 more source

Expression of ceruloplasmin in cavernosal tissue of paradoxical sleep deprived rats

Sleep Science, 2012
Objective: Ceruloplasmin (Cp) is a copper-binding protein expressed in several tissues that plays distinct functions depending on the physiological context.
Monica Levy Andersen, Camila Guindalini, Tathiana Aparecida Alvarenga, Fernanda de Mattos Egydio, Sergio Tufik   +4 more
doaj   +1 more source

Plasma zinc, copper and serum ceruloplasmin levels of autism spectrum disorder children in Bangladesh

Heliyon, 2023
Neural and cognitive processes require zinc and copper homeostasis and a normal zinc/copper ratio. Ceruloplasmin, an intrinsic antioxidant protein, maintains copper homeostasis, which might also influence autism spectrum disorder (ASD).
Umme Raihan Siddiqi, Shelina Begum, Shorifa Shahjadi, Sharmin Afroz, Syeda Nusrat Mahruba, Jobaida Parvin, Md Mahbubur Rahman   +6 more
doaj   +1 more source

Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients

Biomarker Insights, 2006
A dysfunction in copper homeostasis seems to occur in Alzheimer's disease (AD). We previously evidenced that an excess of non-ceruloplasmin-copper (NCC) correlated with the main functional, anatomical as well as cerebrospinal markers of the disease.
Rosanna Squitti, Carlo C. Quattrocchi, Gloria Dal Forno, Piero Antuono, David R. Wekstein, Concetta R. Capo, Carlo Salustri, Paolo M. Rossini   +7 more
doaj   +2 more sources

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells. [PDF]

PLoS ONE, 2016
Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role in efflux of iron from cells, but has additional functions.
Danny Ramos, David Mar, Michael Ishida, Rebecca Vargas, Michaella Gaite, Aaron Montgomery, Maria C Linder   +6 more
doaj   +1 more source

Sertoli Cells Synthesize and Secrete a Ceruloplasmin-Like Protein [PDF]

, 1983
Sertoli cells synthesize and secrete a ceruloplasmin-like protein (testicularceruloplasmin) that is immunologically similar to serum ceruloplasmin.
Michael K. Skinner, Griswold, Michael D., Michael D. Griswold, Skinner, Michael K.   +3 more
core   +1 more source

Ceruloplasmin and the Extent of Heart Failure in Ischemic and Nonischemic Cardiomyopathy Patients

Mediators of Inflammation, 2013
Objective. Ceruloplasmin was elevated in patients with coronary heart disease, but the relationship between ceruloplasmin and heart failure was still unknown.
Yifei Xu, Haiyan Lin, Ying Zhou, Gang Cheng, Geng Xu   +4 more
doaj   +1 more source

High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study

Behavioral and Brain Functions, 2008
Background Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders.
Celik Hakim, Savas Haluk, Bulut Mahmut, Selek Salih, Virit Osman, Erel Ozcan, Herken Hasan   +6 more
doaj   +1 more source