Results 101 to 110 of about 52,504 (265)

Incidence and Variants of Posterior Arch Defects of the Atlas Vertebra

Radiology Research and Practice, 2013
In order to describe the incidence and existing variants of congenital anomalies of the atlas vertebrae in a Caucasian population, we examined 1069 CT scans of the upper cervical spine. We found 41 cases with altered atlas vertebrae, representing 3.8% of
Sebastian Guenkel, Sladjana Schlaepfer, Sonja Gordic, Guido A. Wanner, Hans-Peter Simmen, Clément M. L. Werner   +5 more
doaj   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Atlantodental Osteoarthritis as a Cause of Upper Cervical Myelopathy: A Case Report

Eurasian Journal of Medicine, 2019
Atlantoaxial instability frequently causes extrinsic cervical myelopathy via anterior displacement of the posterior arch of the atlas. However, upper cervical myelopathy resulting from atlantodental osteoarthritis with the hypertrophic dens due to ...
Suat Eren, Mecit Kantarci, Orhan Deniz
doaj  

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Atlas realignment as novel approach to whiplash recovery: A case study on cervical stability and neurovascular flow

Interdisciplinary Neurosurgery
This case report illustrates the significant improvement of a male patient suffering from whiplash-associated disorder (WAD) following atlas vertebral realignment. The patient, who experienced headaches, neck pain, brain fog, a heavy feeling in the head,
Jonathan Verderame, Muhammad Shakib Arslan, Zaheer Abbas   +2 more
doaj   +1 more source

A further study of the Quaternary antelopes of Shelter Cave, New Mexico [PDF]

, 1932
Since the preliminary description of Tetrameryx? conklingi from Quaternary deposits in Shelter Cave, New Mexico, additional materials of this interesting antilocaprid species have been obtained in the course of further excavations in the cavern by Mr. R.
Stock, Chester
core  

Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]

, 2012
OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S., Awe, Olatilewa, Elliott, Melanie B., Jallo, Jack I., Oshinsky, Michael L.   +4 more
core   +2 more sources

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction [PDF]

, 2018
The brain communicates with the spinal cord through numerous axon tracts that arise from discrete nuclei, transmit distinct functions, and often collateralize to facilitate the coordination of descending commands.
Blackmore, Murray G., Maunze, Brian, Tsoulfas, Pantelis, Wang, Yunfang, Wang, Zimei   +4 more
core   +2 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source